An Intervention Trial in High-Risk Asbestos-exposed Persons

  • Jerry W. McLarty
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 320)


Lung cancer, the treatment of which is essentially no more effective today than it was 20 years ago, remains the major cause of cancer mortality in the United States, killing more than 140,000 persons annually. Persons who are occupationally exposed to asbestos are at extremely high risk for lung cancer, from 10 to 50 or more times higher than normal—depending upon their smoking history. In the following discussion, we present the study design for an ongoing intervention trial among 750 asbestos workers in Tyler, Texas. β-Carotene and retinol are being used as the chemopreventive agents and an intermediate end point, sputum atypia, as the measure of response. Some results of baseline data analysis (before initiation of treatment) will be presented below. Findings of toxicity, recruitment, and compliance will also be discussed.


Serum Vitamin Lung Cancer Risk Asbestos Exposure Cervical Dysplasia Sputum Specimen 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Jerry W. McLarty
    • 1
  1. 1.Department of Epidemiology/BiomathematicsThe University of Texas Health Science Center at TylerTylerUSA

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