Heterogeneity of a Herpes Simplex Virus Clinical Isolate Exhibiting Resistance to Acyclovir and Foscarnet

  • Emanuela Pelosi
  • Karen A. Hicks
  • Stephen L. Sacks
  • Donald M. Coen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 312)

Summary

Resistance of herpes simplex virus to acyclovir is a problem of growing clinical importance. Acyclovir-resistance can be due either to mutations in the viral thymidine kinase gene or in the viral DNA polymerase gene. Although clinical resistance has most frequently been associated with thymidine kinase alterations, heterogeneity in clinical isolates has not been addressed frequently. The potential for such heterogeneity has been emphasized by a report describing a pathogenic clinical isolate containing within its population at least one thymidine kinase-proficient DNA polymerase mutant as well as mutants exhibiting thymidine kinase-deficiency (Sacks, et al., 1989). We provide here additional characterization of this isolate and speculations regarding its significance.

Keywords

Herpes Simplex Virus Type Thymidine Kinase Herpes Simplex Virus Thymidine Kinase Thymidine Kinase Activity Plaque Reduction Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Emanuela Pelosi
    • 1
  • Karen A. Hicks
    • 1
  • Stephen L. Sacks
    • 2
  • Donald M. Coen
    • 1
  1. 1.Department of Biological Chemistry and Molecular PharmacologyHarvard Medical SchoolBostonUSA
  2. 2.Division of Infectious DiseasesUniversity of British ColumbiaVancouverCanada

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