Delta Virus as a Vector for the Delivery of Biologically-Active RNAs: Possibly a Ribozyme Specific for Chronic Hepatitis B Virus Infection
RNA species have been designed that demonstrate specific biological activities. Examples include the antisense RNA oligonucleotides (Weintraub et al., 1985) and catalytic RNAs that act as endoribonucleases (Haseloff and Gerlach, 1988). And, recently (Ellington and Szostak 1990) have developed an even more general method of allowing the selection, in the test tube, of RNA species that can bind to a chosen domain, for example on an RNA, DNA, or protein.
KeywordsHepatitis Delta Virus Chloramphenicol Acetyl Transferase Woodchuck Hepatitis Virus Specific Biological Activity Thymidine Kinase Promotor
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