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Delta Virus as a Vector for the Delivery of Biologically-Active RNAs: Possibly a Ribozyme Specific for Chronic Hepatitis B Virus Infection

  • Sen-Yung Hsieh
  • John Taylor
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 312)

Abstract

RNA species have been designed that demonstrate specific biological activities. Examples include the antisense RNA oligonucleotides (Weintraub et al., 1985) and catalytic RNAs that act as endoribonucleases (Haseloff and Gerlach, 1988). And, recently (Ellington and Szostak 1990) have developed an even more general method of allowing the selection, in the test tube, of RNA species that can bind to a chosen domain, for example on an RNA, DNA, or protein.

Keywords

Hepatitis Delta Virus Chloramphenicol Acetyl Transferase Woodchuck Hepatitis Virus Specific Biological Activity Thymidine Kinase Promotor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Chen, P.J., Kalpana, G., Goldberg, J., Mason, W., Werner, B., Gerin, J., and Taylor, J., 1986, Structure and replication of the genome of hepatitis delta virus, Proc. Natl. Acad. Sci. USA, 83:8774.PubMedCrossRefGoogle Scholar
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Sen-Yung Hsieh
    • 1
  • John Taylor
    • 1
  1. 1.Fox Chase Cancer CenterPhiladelphiaUSA

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