Roles for Tgfß1 in Chick Embryo Cell Transformation

  • Esmond J. Sanders
Part of the NATO ASI Series book series (NSSA, volume 231)

Abstract

Early embryonic development is characterized by the occurrence of sequential epithelial-to-mesenchymal and mesenchymal-to-epithelial cell transformations, each of which results in the appearance of a novel cell population. The factors that trigger and influence these early cell transformations are unknown, but may rely on changes in the complement of receptors at the cell surface, changes in the surrounding extracellular matrix, or changes in the influence of local soluble factors. Such events are well-illustrated by the differentiation of the various divisions of the early mesoderm in the avian embryo (Sanders, 1989; 1991). In this sequence, cells of the epithelial epiblast are first transformed into mesenchyme by passage through the primitive streak -- a region in which as yet undisclosed cell events result in localized phenotypic transformation (Bellairs, 1986; Sanders, 1986). After emergence from the primitive streak, the mesodermal cells align paraxially to form the transient segmental plate from which, by mesenchymal-to-epithelial transformation, somites form (Bellairs, 1979). Further differentiation of this tissue necessitates dispersal of its ventromedial portion into sclerotome, as a result of a transformation back into the mesenchymal phenotype. Nothing is known of the factors that precipitate this dispersal.

Keywords

Migration Adenocarcinoma Compaction Laminin Retinoid 

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References

  1. Akhurst, R.J., Lehnert, S.A., Faissner, A., and Duffie, E., 1990, TGFß in murine morphogenetic processes: the early embryo and cardiogenesis, Development, 108: 645–656.PubMedGoogle Scholar
  2. Bellairs, R., 1979, The mechanism of somite segmentation in the chick embryo, J. Embryol. exp. Morph., 51: 227–243.PubMedGoogle Scholar
  3. Bellairs, R., 1986, The primitive streak, Anat. Embryol., 174: 1–14.PubMedCrossRefGoogle Scholar
  4. Brown, A.J., and Sanders, E.J., 1991, Interactions between mesoderm cells and the extracellular matrix following gastrulation in the chick embryo, J. Cell Sci., 99: 431–441.PubMedGoogle Scholar
  5. Carrington, J.L., and Reddi, A.H., 1990, Temporal changes in the response of chick limb bud mesodermal cells to transforming growth factor β;-type 1, Expl. Cell Res., 186: 368–373.CrossRefGoogle Scholar
  6. Choy., M., Armstrong, M.T., and Armstrong, P.B., 1991, Transforming growth factor-ßl localized within the heart of the chick embryo, Anat. Embryol., 183: 345–352.PubMedCrossRefGoogle Scholar
  7. Cooke, J., and Wong, A., 1991, Growth-factor-related proteins that are inducers in early amphibian development may mediate similar steps in amniote (bird) embryogenesis, Development, 111: 197–212.PubMedGoogle Scholar
  8. Cross, M., and Dexter, T.M., 1991, Growth factors in development, transformation, and tumorigenesis, Cell, 64: 271–280.PubMedCrossRefGoogle Scholar
  9. Dasch, J.R., Pace, D.R., Waegell, W., Inenaga, D., and Ellingsworth, L., 1989, Monoclonal antibodies recognizing transforming growth factor-ß, J. Immunol., 142: 1536–1541.PubMedGoogle Scholar
  10. Hamburger, V., and Hamilton, H.L., 1951, A series of normal stages in the development of the chick embryo, J. Morph., 88: 49–92.CrossRefGoogle Scholar
  11. Hayamizu, T.F., Sessions, S.K., Wanek, N., and Bryant, S.V., 1991, Effects of localized application of transforming growth factor ßl on developing chick limbs, Dev. Biol., 145: 164–173.PubMedCrossRefGoogle Scholar
  12. Heine, U.I., Munoz, E.F., Flanders, K.C., Roberts, A.B., and Sporn, M.B., 1990, Colocalization of TGF-ßl and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis, Development, 109: 29–36.PubMedGoogle Scholar
  13. Ignotz, R.A., and Massague, J., 1986, Transforming growth factor-ß stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix, J. Biol. Chem., 261: 4337–4345.PubMedGoogle Scholar
  14. Ignotz, R.A., and Massague, J., 1987, Cell adhesion protein receptors as targets for transforming growth factor-ß action, Cell, 51: 189–197.PubMedCrossRefGoogle Scholar
  15. Kulyk, W.M., Rodgers, B.J., Greer, K., and Kosher, R.A., 1989, Promotion of embryonic chick limb cartilage differentiation by transforming growth factor-ß, Dev. Biol., 135: 424–430.PubMedCrossRefGoogle Scholar
  16. Lucas, P.A., and Caplan, A.I., 1988, Chemotactic response of embryonic limb bud mesenchymal cells and muscle-derived fibroblasts to transforming growth factor-ß, Conn. Tiss. Res., 18: 1–17.CrossRefGoogle Scholar
  17. Massague, J., 1990, The transforming growth factor-ß family, Ann. Rev. Cell Biol., 6: 597–641.PubMedCrossRefGoogle Scholar
  18. Melton, D.A., 1991, Pattern formation during animal development, Science, 252: 234–241.PubMedCrossRefGoogle Scholar
  19. Mitrani, E., and Shimoni, Y., 1990, Induction by soluble factors of organized axial structures in chick epiblasts, Science, 247: 1092–1094.PubMedCrossRefGoogle Scholar
  20. Mitrani, E., Ziv, T., Thomsen, G., Shimoni, Y., Melton, D.A., and Bril, A., 1990, Cell, 63: 495–501.PubMedCrossRefGoogle Scholar
  21. Mooradian, D.L., Lucas, R.C., Weatherbee, J.A., and Furcht, L.T., 1989, Transforming growth factor-ßi binds to immobilized fibronectin, J. Cell. Biochem., 41: 189–200.PubMedCrossRefGoogle Scholar
  22. New, D.A.T., 1955, A new technique for the cultivation of the chick embryo in vitro, J. Embryo’. exp. Morph., 3: 320–331.Google Scholar
  23. Paralkar, V.M., Vukicevic, S., and Reddi, A.H., 1991, Transforming growth factor ß type 1 binds to collagen IV of basement membrane matrix: implications for development, Dev. Biol., 143: 303–308.PubMedCrossRefGoogle Scholar
  24. Potts, J.D., and Runyan, R.B., 1989, Epithelial-mesenchymal cell transformation in the embryonic heart can be mediated, in part, by transforming growth factor ß, Dev. Biol., 134: 392–401.PubMedCrossRefGoogle Scholar
  25. Rizzino, A., 1988, Transforming growth factor-ß: multiple effects on cell differentiation and extracellular matrices, Dev. Biol., 130: 411–422.PubMedCrossRefGoogle Scholar
  26. Roberts, A.B., Flanders, K.C., Heine, U.I., Jakowlew, S., Kondaiah, P., Kim, S.J., and Sporn, M.B., 1990a, Transforming growth factor-ß: multifunctional regulator of differentiation and development, Phil. Trans. R. Soc. Lond., 327: 145–154.CrossRefGoogle Scholar
  27. Roberts, A.B., Heine, U.I., Flanders, K.C., and Sporn, M.B., 1990b, Transforming growth factor-ß. Major role in regulation of extracellular matrix, Ann. N.Y. Acad. Sci., 580: 225–232.PubMedCrossRefGoogle Scholar
  28. Rosa, F., Roberts, A.B., Danielpour, D., Dart, L.L., Sporn, M.B., and Dawid, I.B., 1988, Mesoderm induction in amphibians: the role of TGF82-like factors, Nature, 239: 783–785.Google Scholar
  29. Sanders, E.J., 1980, The effect of fibronectin and substratum-attached material on the spreading of chick embryo mesoderm cells in vitro, J. Cell Sci., 44: 225–242.PubMedGoogle Scholar
  30. Sanders, E.J., 1986, Mesoderm migration in the early chick embryo, in: “Developmental Biology. A Comprehensive Synthesis,” volume 2, L. Browder, ed., Plenum, New York, pp. 449–480.Google Scholar
  31. Sanders, E.J., 1989, “The Cell Surface in Embryogenesis and Carcinogenesis,” Telford Press, Caldwell, New Jersey.Google Scholar
  32. Sanders, E.J., 1991, Morphogenesis of the mesoderm in early avian development: sequential phenotypic transformations, in: “Growth Regulation and Carcinogenesis,” volume 2, W.R. Paukovitz, ed., CRC Press, Boca Raton, pp. 233–245.Google Scholar
  33. Sanders, E.J., and Prasad, S., 1991, Possible roles for TGFß1 in the gastrulating chick embryo, J. Cell Sci., 99: 617–626.PubMedGoogle Scholar
  34. Stern, C.D., Ireland, G.W., Herrick, S.E., Gherardi, E., Gray, J., Perryman, M., and Stoker, M., 1990, Epithelial scatter factor and the development of the embryonic axis, Development, 110: 1271–1284.PubMedGoogle Scholar
  35. Taub, M., Wang, Y., Szczesny, T.M., and Kleinman, H.K., 1990, Epidermal growth factor or transforming growth factor a is required for kidney tubulogenesis in matrigel cultures in serum-free medium, Proc. natn. Acad. Sci. U.S.A., 87: 4002–4006.CrossRefGoogle Scholar
  36. Veini, M., and Hara, K., 1975, Changes in the differentiation tendencies of the hypoblast-free Hensen’s node during `gastrulation’ in the chick embryo, Wilhelm Roux Arch., 177: 89–100.CrossRefGoogle Scholar
  37. Wedden, S., Thaller, C., and Eichele, G., 1990, Targeted slow-release of retinoids into chick embryos, Methods Enzymol., 190: 201–209.PubMedCrossRefGoogle Scholar
  38. Welch, D.R., Fabra, A., and Nakajima, M., 1990, Transforming growth factor B stimulates mammary adenocarcinoma cell invasion and metastatic potential, Proc. natn. Acad. Sci. U.S.A., 87: 7678–7682.CrossRefGoogle Scholar
  39. Weller, A., Sorokin, L., Illgen, E-M., Ekblom, P., 1991, Development and growth of mouse embryonic kidney in organ culture and modulation of development by soluble growth factors, Dev. Biol., 144: 248–261.PubMedCrossRefGoogle Scholar
  40. Whitman, M., and Melton, D.A., 1989, Growth factors in early embryogenesis, Ann. Rev. Cell Biol., 5: 93–117.PubMedCrossRefGoogle Scholar
  41. Zagris, N., and Chung, A.E., 1990, Distribution and functional role of laminin during induction of the embryonic axis in the chick embryo, Differentiation, 43: 81–86.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Esmond J. Sanders
    • 1
  1. 1.Department of PhysiologyUniversity of Alberta EdmontonAlbertaCanada

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