Abstract
Small differences in intraischemic brain temperature can significantly affect the neuropathological and functional outcome following transient global forebrain ischemia. Lowering intraischemic brain temperature by 2–3°C in the rat prevents the delayed neuronal damage that typically occurs in zones of selective vulnerability following 20 minutes of ischemia (Busto et al, 1987), and improves the behavioral outcome following a 10 min insult (vanDijk et al, 1991). Conversely, raising the intraischemic brain temperature to 39°C significantly worsen ischemic outcome and increased the vulnerability of resistant brain areas (Dietrich et al, 1990a). The protective effect of intraischemic hypothermia was not associated with the reduction in the degree of ischemia as reflected by the magnitude of energy metabolites depletion or cerebral blood flow recluction (Busto et al, 1987; Busto et al, 1989), suggesting that Some other mechanism prevails.
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Sternau, L.L., Globus, M.YT., Dietrich, W.D., Martinez, E., Busto, R., Ginsberg, M.D. (1992). Ischemia-Induced Neurotransmitter Release: Effects of Mild Intraischemic Hyperthermia. In: Globus, M.YT., Dietrich, W.D. (eds) The Role of Neurotransmitters in Brain Injury. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3452-5_6
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DOI: https://doi.org/10.1007/978-1-4615-3452-5_6
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