Focal Cold Injury Alters the Pharmacodynamics of Pentobarbital and the Metabolic Response to Anesthetics: Evidence for Functional Cerebral Depression

  • David Archer


Superficial focal cold injury to the cerebral cortex has been previously shown to be associated with widespread depression of glucose utilization (CMRglu), which is maximal 3 days after the injury (Pappius, 1981). These authors (Pappius, 1981), Pappius and Wolfe, 1983, Pappius et al, 1988) have suggested that the decrease in CMRglu represents functional cerebral depression, and have presented evidence to support a role for cortical monoamines (serotonin and noradrenaline) in this phenomenon. Ginsberg et al, in a model of focal thrombotic infarction, have also observed widespread metabolic effects and have interpreted these findings to represent functional diaschisis (Ginsberg et al, 1989).


Cereb Blood Flow Cold Injury Injured Animal Anesthetic Requirement Serotonin Turnover 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • David Archer
    • 1
  1. 1.Research Laboratory, Department of Anaesthesia, Foothills HospitalThe University of CalgaryCalgaryCanada

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