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Moderate Hypothermia Reduces Blood-Brain Barrier Disruption Following Traumatic Brain Injury

  • Ji Y. Jiang
  • Bruce G. Lyeth
  • Manisha Kapasi
  • John Povlishock

Abstract

Several studies indicate that hypothermia may modulate pathological responses to experimental traumatic brain injury (TBI). For example, induction of hypothermia (30°C) prior to fluid percussion injury in rats reduces mortality (Clifton et al., 1991) and induction of hypothermia (30° or 33°C) 5 minutes after injury reduces motor deficits (Clifton et al., 1991). The mechanisms of hypothermic protection in TBI are presently not known. Recent data, however, now indicate that hypothermia (30°C) significantly reduces the increase in acetylcholine (ACh) concentration in cerebrospinal fluid (CSF) of TBI rats (Lyeth et al., 1991).

Keywords

Traumatic Brain Injury Brain Temperature Cereb Blood Flow Moderate Hypothermia Fluid Percussion Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Busto, R., Dietrich, W.D., Globus, M.Y.T., Valdes, I., Scheinber, P., and Ginsberg, M.D., 1987, Small differences in intra ischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab 7:729–738.PubMedCrossRefGoogle Scholar
  2. Busto, R., Dietrich, W.D., Globus, M.Y.T., Castella, Y., and Ginsberg, M.D. 1989a, Postischemic moderate hypothermia inhabits CA1 hippocampal ischemic neuronal injury. J Cereb Blood Flow Metab 9(suppl 1):266.Google Scholar
  3. Busto, R., Globus, M.Y.T., Dietrich, D., Martinez, E., Valdes, I., and Ginsberg, M.D., 1989b, Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke 20:904–910.PubMedCrossRefGoogle Scholar
  4. Chopp, M., Knight, R., Tidwell, C.D., Helpern, J.A., Brown, E., and Welch, K.M.A., 1989, The metabolic effects of mild hypothermia on global cerebral ischemia and recirculation in the cat: comparison to normothermia and hyperthermia. J Cereb Blood Flow Metab 9:141–148.PubMedCrossRefGoogle Scholar
  5. Clifton, G.L., Taft, W.C., Blair, R.E., Choi, S.F., and DeLorenzo, R.J., 1989, Conditions for pharmacologic evaluation in the gerbil model of forebrain ischemia. Stroke 20:1545–1552.PubMedCrossRefGoogle Scholar
  6. Clifton, G.L., Jiang, J.Y., Lyeth, B.G., Jenkins, L.W., Hamm, R.J., and Hayes, R.L., 1991, Marked protection by moderate hypothermia after experimental traumatic brain injury. J Cereb Blood Flow Metab 11:114–121.PubMedCrossRefGoogle Scholar
  7. Dempsey, R., Combs, D.J., Maley, M.E., Cowen, D.E., Roy, M.W., and Donaldson, D.L., 1987, Moderate hypothermia reduces post ischemic edema development and leukotriene production. Neurosurgery 21:177–181.PubMedCrossRefGoogle Scholar
  8. Dietrich, W.D., Busto, R., Halley, M., and Valdes, I., 1990, The importance of brain temperature in alterations of the blood-brain barrier following cerebral ischemia. J Neuropathol Exp Neurol 49:486–497.PubMedCrossRefGoogle Scholar
  9. Faden, A.I., Demediuk, P., Panter, S.S., and Vink, R., 1989, The role of excitatory amino acid and NMDA receptors in traumatic brain injury. Science 244:798–800.PubMedCrossRefGoogle Scholar
  10. Gingsberg, M.D., Busto, R., Castella, Y., Valdes, I., and Loor, J. 1989, The protective effect of moderate intraischemic brain hypothermia is associated with improved postischemic glucose utilization and blood flow. J Cereb Blood Flow Metab 9(suppl. 1):380.Google Scholar
  11. Hayes, R.L., Jenkins, L.W., Lyeth, B.G., Balster, R.L., Robinson, S.E., Miller, L.P., Clifton, G.L., and Young, H.F., 1988, Pretreatment with phencyclidine, an Nmethyl-D aspartate receptor antagonist, attenuates long-term behavioral deficits in the rat produced by traumatic brain injury. J Neurotrauma 5:287–302.Google Scholar
  12. Hoffman, W.E., Werner, C., Baughman, V.L., Thomas, C., Miletich, D.J., and Albrecht, R.F., 1991, Postischemic treatment with hypothermia improves outcome from incomplete cerebral ischemia in rats. J Neurosurg Anesthesiol 3:34–38.PubMedCrossRefGoogle Scholar
  13. Jiang, J.Y., Lyeth, B.G., Clifton, G.L., Jenkins, L.W., Hamm, R.J., and Hayes, R.L., 1991, Relationship between body and brain temperature in traumatically brain-injured rodents. J Neurosurg 74:492–496.PubMedCrossRefGoogle Scholar
  14. Lyeth, B.G., Dixon, C.E., Jenkins, L.W., Hamm, R.J., Alberico, A., Young. H.F., Stonnington, H.H., and Hayes, R.L., 1988, Effects of scopolamine treatment on long-term behavioral deficits following concussive brain injury to the rat. Brain Res 452:39–48.PubMedCrossRefGoogle Scholar
  15. Lyeth, B.G., Jiang, J.Y., Robinson, S.E., Guo, H., Jenkins, L.W., and Hayes, R.L., 1991, Hypothermia blunts acetylcholine increase in CSF in traumatically brain injured rats. Soc Neurosci Abstr (in press).Google Scholar
  16. McIntosh, T.K., Vink, R., Noble, L., Yamakami, I., Soares, H., and Faden, A.L., 1989a, Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model. Neuroscience 28:233–244.PubMedCrossRefGoogle Scholar
  17. McIntosh, T.K., Vink, R., Soares, H., Hayes, R.L., and Simmon, R., 1989b, Effects of N-Methyl-D-Aspartate receptor blocker MK–801 on neurologic function after experimental brain injury. J Neurotrauma 6:247–259.PubMedCrossRefGoogle Scholar
  18. Pardridge, W.M., 1985, Cerebral vascular permeability status in brain injury, in: Central Nervous System Trauma Status Report, D.P. Becker, and J.T. Povlishock, eds., NINCDS & NIH, Washington, D.C..Google Scholar
  19. Povlishock, J.T., 1985, The morphopathologic responses to experimental head injuries of varying severities, in: Central Nervous System Trauma Status Report, D.P. Becker, and J.T. Povlishock, eds., NINCDS & NIH, Washington, D.C..Google Scholar
  20. Povlishock, J.T., and Lyeth, B.G., 1989, Traumatically induced blood-brain barrier disruption: A conduit for the passage of circulating excitatory neurotransmitters. Soc Neurosci Abstr 15:1113Google Scholar
  21. Robinson, S.E., Martin, R.M., Davis, T.R., Gyenes, C.A., Ryland, J.E., and Enters, E.K., 1990, The effect of acetylcholine depletion on behavior following traumatic brain injury. Brain Res 509:41–46.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Ji Y. Jiang
    • 1
  • Bruce G. Lyeth
    • 1
  • Manisha Kapasi
    • 2
  • John Povlishock
    • 2
  1. 1.Division of NeurosurgeryMedical College of VirginiaRichmondUSA
  2. 2.Department of AnatomyMedical College of VirginiaRichmondUSA

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