Moderate Hypothermia Reduces Blood-Brain Barrier Disruption Following Traumatic Brain Injury
Several studies indicate that hypothermia may modulate pathological responses to experimental traumatic brain injury (TBI). For example, induction of hypothermia (30°C) prior to fluid percussion injury in rats reduces mortality (Clifton et al., 1991) and induction of hypothermia (30° or 33°C) 5 minutes after injury reduces motor deficits (Clifton et al., 1991). The mechanisms of hypothermic protection in TBI are presently not known. Recent data, however, now indicate that hypothermia (30°C) significantly reduces the increase in acetylcholine (ACh) concentration in cerebrospinal fluid (CSF) of TBI rats (Lyeth et al., 1991).
KeywordsPermeability Ischemia Albumin Neurol Sponge
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