Moderate Hypothermia Reduces Blood-Brain Barrier Disruption Following Traumatic Brain Injury

  • Ji Y. Jiang
  • Bruce G. Lyeth
  • Manisha Kapasi
  • John Povlishock


Several studies indicate that hypothermia may modulate pathological responses to experimental traumatic brain injury (TBI). For example, induction of hypothermia (30°C) prior to fluid percussion injury in rats reduces mortality (Clifton et al., 1991) and induction of hypothermia (30° or 33°C) 5 minutes after injury reduces motor deficits (Clifton et al., 1991). The mechanisms of hypothermic protection in TBI are presently not known. Recent data, however, now indicate that hypothermia (30°C) significantly reduces the increase in acetylcholine (ACh) concentration in cerebrospinal fluid (CSF) of TBI rats (Lyeth et al., 1991).


Traumatic Brain Injury Brain Temperature Cereb Blood Flow Moderate Hypothermia Fluid Percussion Injury 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Ji Y. Jiang
    • 1
  • Bruce G. Lyeth
    • 1
  • Manisha Kapasi
    • 2
  • John Povlishock
    • 2
  1. 1.Division of NeurosurgeryMedical College of VirginiaRichmondUSA
  2. 2.Department of AnatomyMedical College of VirginiaRichmondUSA

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