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Islet β-Cell Regeneration and Reg Genes

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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 321)

Abstract

We have proposed a unifying model for the action of alloxan and streptozotocin on pancreatic β-cells.1-5 Central to the model are breaks in the nuclear DNA of β-cells resulting from either an accumulation of oxygen radicals or alkylation of DNA. These breaks induce DNA repair involving the activation of poly(ADP-ribose) synthetase, which uses cellular NAD as a substrate; as a result, intra-cellular levels of NAD fall dramatically. The fall in cellular NAD inhibits the cellular activities including insulin synthesis, thus the β-cell ultimately dies.

Keywords

Exocrine Cell Synthetase Inhibitor Pancreatic Stone Normal Islet Large Open Reading Frame 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  1. 1.Department of BiochemistryTohoku University School of MedicineSendai, MiyagiJapan
  2. 2.Shionogi Research LaboratoriesShionogi & Co. Ltd.OsakaJapan
  3. 3.Department of BiochemistryTohoku University of MedicineSendai, MiyagiJapan

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