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The Effects of IGF-I and IGF-II on Cell Growth and Differentiation in the Central Nervous System

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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 321)

Abstract

The role of growth factors in central nervous system (CNS) function has been the focus of much research within the last decade. While much of the attention centered around nerve growth factor initially, other growth factors have also been shown to have a potential role in nervous system function. Among the most intriguing of these are the insulin-like growth factors I and II (IGF-I and IGF-II). As early as 1941, a report was published in which crude pituitary extracts were shown to increase the brain size of tadpoles.1 Later studies following up on this initial observation demonstrated that the trophic factor involved in this response was growth hormone (GH) dependent2 and that the factor causing the increased growth was IGF-I.3

Keywords

Nerve Growth Factor Myelin Basic Protein Neurite Formation Stimulate Neurite Outgrowth Tubulin mRNA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    S. Zamenhof, Stimulation of the proliferation of neurons by growth hormone. I: experiments on tadpoles, Growth. 5:123–39 (1941).Google Scholar
  2. 2.
    V.R. Sara, L. Lazarus, M.C. Stuart, and T. King, Fetal brain growth: selective action by growth hormone, Science. 186:446–47 (1974).PubMedCrossRefGoogle Scholar
  3. 3.
    V.R. Sara, C. Carlsson-Skwirut, C. Andersson, E. Hall, B. Sjogren, A. Holmgren, and H. Jornvall, Characterization of somatomedins from human brain: identification of a variant form of 10F-I, Proc Natl Acad Sci USA. 83:4904–07 (1986).PubMedCrossRefGoogle Scholar
  4. 4.
    K.R Duffy, W.M. Pardridge, and R.G. Rosenfeld, Human blood-brain barrier insulin-like growth factor receptor, Metabolism. 37:136–42 (1988).PubMedCrossRefGoogle Scholar
  5. 5.
    R.G. Rosenfeld, H. Pham, B.T. Keller, R.T. Borchardt, and W.M. Pardridge, Demonstration and structural comparison of receptors for insulin-like growth factor-I and-II (IOF-I and-II) in brain and bloodbrain barrier, Biochem Biophys Res Commun. 149:159–66 (1987).PubMedCrossRefGoogle Scholar
  6. 6.
    M.W. Schwartz, A.J. Sipols, S.E. Kahn, D.P. Latteman, G.J. Taborsky, R.N. Bergman, S.C. Woods, and D. Porte, Jr., Kinetics and specificity of insulin uptake from plasma in cerebrospinal fluid, Am J Physiol. 259:E378–83 (1990).PubMedGoogle Scholar
  7. 7.
    P.K. Lund, B.M. Moats-Staats, M.A. Hynes, J.G. Simmons, M. Jansen, A.J. D’Ercole, and J.J. Van Wyk, Somatomedin-C/Insulin-like growth factor-I and Insulin-like growth factor-II mRNAs in rat fetal and adult tissues, J Biol Chem. 261:14539–44 (1986).PubMedGoogle Scholar
  8. 8.
    L.J. Murphy, G.I. Bell, and H.G. Friesen, Tissue distribution of insulin-like growth factor I and II messenger ribonucleic acid in the adult rat, Endocrinology. 120:1279–82 (1987).PubMedCrossRefGoogle Scholar
  9. 9.
    P. Rotwein, S.K. Burgess, J.D. Milbrandt, and J.E. Krause, Differential expression of insulin-like growth factor genes in the central nervous system, Proc Natl Acad Sci USA. 85:265–69 (1988).PubMedCrossRefGoogle Scholar
  10. 10.
    F. Stylianpoulou, J. Herbert, M.B. Soares, and A. Efstratiadis, Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system, Proc Natl Acad Sci USA. 85:141–45 (1988).CrossRefGoogle Scholar
  11. 11.
    T.J. Lauterio, P.P. Aravich, and P. Rotwein, Divergent effects of insulin on insulin-like growth factor-II gene expression in the rat hypothalamus, Endocrinology. 126:392–98 (1990).PubMedCrossRefGoogle Scholar
  12. 12.
    J.A. Romanus, Y.W.H. Yang, S.O. Adams, A.N. Sofair, L.Y.H. Tseng, S.P. Nissley, and M.M. Rechler, Synthesis of insulin-like growth factor II (IOF-II) in fetal rat tissues: translation of I0F-II ribonucleic acid and processing of pre-pro-IOF-II, Endocrinology. 122:709–16 (1988).PubMedCrossRefGoogle Scholar
  13. 13.
    G. Haselbacher and R. Humbel, Evidence for two species of insulin-like growth factor II (IOF-II and “Big 10F-II) in human spinal fluid, Endocrinology. 110:1822–24 (1982).PubMedCrossRefGoogle Scholar
  14. 14.
    V.R. Sara and C. Carlsson-Skwimt, Insulin-like growth factors in the central nervous system: biosynthesis and biological role. in: “Growth Factors: From Genes To Clinical Applications”, V.R. Sara, K. Hall, and H. Low, eds., Raven Press, New York (1990).Google Scholar
  15. 15.
    V.R. Sara, K. Hall, H. von Holtz, R. Humbel, B. Sjogren, and L. Wetterberg, Evidence for the presence of specific receptors for insulin-like growth factor I (IOF-I) and 2 (IOF-2) and insulin throughout the human brain, Neurosci Lett. 34:39–44 (1982).PubMedCrossRefGoogle Scholar
  16. 16.
    S. Gammeltoft, G.K. Haselbacher, R.E. Humbel, M. Fehlmann, and E. Van Obberghen, Two types of receptor for insulin-like growth factors in mammalian brain, Embo J. 4:3407–12 (1985).PubMedGoogle Scholar
  17. 17.
    A. Ota, Z. Shen-Orr, C.T. Roberts Jr, and D. LeRoith, TPA-induced neurite formation in a neuroblastoma cell line (SH-SY5Y) is associated with increased 10F-I receptor mRNA and binding, Mol Brain Res. 6:69–76 (1989).PubMedCrossRefGoogle Scholar
  18. 18.
    E.R. Froesch, C. Schmid, J. Schwander, and J. Zapf, Actions of insulin-like growth factors, Annu Rev Physiol. 47:443–68 (1985).PubMedCrossRefGoogle Scholar
  19. 19.
    M.M. Rechler and S.P. Nissley, The nature and regulation of receptors for the insulin-like growth factors, Annu Rev Physiol. 47:427–42 (1985).CrossRefGoogle Scholar
  20. 20.
    W.H. Daughaday and P. Rotwein, Insulin-like growth factors I and n. Peptide, inessenger ribonucleic acid and gene sttuctures, serum and tissue concentrations, Endocr Rev. 10:68–91 (1989).PubMedCrossRefGoogle Scholar
  21. 21.
    M. Bothwell, Insulin and somatomedin MSA promote nerve growth factor-independent neurite formation by cultured chick dorsal root ganglionic sensory neurons, J Neurosci Res. 8:225–31 (1982).PubMedCrossRefGoogle Scholar
  22. 22.
    E. Recio-Pinto, M.M. Rechler, and D.N. Ishii, Effects of insulin, insulin-like growth factor II and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons, J Neurosci. 6:1211–19 (1986).PubMedGoogle Scholar
  23. 23.
    D. Svrzic and D. Schubert, Insulin-like growth factor 1 supports embryonic nerve cell survival, Biochem Biophys Res COmm. 172:54–60 (1990).PubMedCrossRefGoogle Scholar
  24. 24.
    J. Shemer, M.K. Raizada, B.A. Masters, A. Ota, and D. LeRoith, Insulin-like growth factor I receptors in neuronal and glial cells, J Bioi Chem. 262:7693–99 (1986).Google Scholar
  25. 25.
    S.K. Burgess, S. Jacobs, P. Cuatrecasas, and N. Sahyoun, Characterization of a neuronal subtype of insulin-like growth factor I receptor, J Biol Chem. 262:1618–22 (1987).PubMedGoogle Scholar
  26. 26.
    L. Olson, Arer-LeLievre, T. Ebendal, M. Eriksdotter-Nilsson, P. Emfors, A. Henshen, B. Hoffer, M. Giacobmi, P. Mouton, M. Palmer, H. Persson, V. Sara, I. Stromberg, and C. Wetmore, Grafts, growth factors and grafts that make growth factors. in: “Progress in Brain Research”, Vol. 82, S.B. Dunnett and S.J. Richards, eds., Elsevier Science, New York, (1990).Google Scholar
  27. 27.
    R.J. Robbins, J. Rasmussen, F. Naftolin, and I. Torres-Aleman, Growth factors and the developmental neurobiology of the hypothalamus, Acta Paediatr Scand. 367(suppl):93–97 (1990).CrossRefGoogle Scholar
  28. 28.
    S.K. Burgess, N. Sahyoun, S.G. Blanchard, H. LeVine, K-J. Chang, and P. Cuatrecasas, Phorbol ester receptors and protein kinase C in primary neuronal cultures: development and stimulation of endogenous phosphorylation, J Cell Biol. 102:312–19 (1986)PubMedCrossRefGoogle Scholar
  29. 29.
    J.P. Mill, M.V. Chao, and D.N. Ishii, Insulin, insulin-like growth factor II, and nerve growth factor effects on tubulin mRNA levels and neurite formation, Proc Nad Acad Sci USA. 82:7126–30 (1985 ).CrossRefGoogle Scholar
  30. 30.
    D.G. Drubin, S.C. Feinstein, E.M. Shooter, and M.W. Kirscner, Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assemblypromoting factors, J Cell Biol. 101:1799–1807 (1985).PubMedCrossRefGoogle Scholar
  31. 31.
    P. Femyhough, J.P. Mill, J.L. Roberts, and D.N. Ishii, Stabilization oftubulin mRNAs by insulin and insulin-like growth factor I during neurite formation, Mol Brain Res. 6:109–20 (1989).CrossRefGoogle Scholar
  32. 32.
    M.A. Bisby, Axonal transport of labeled protein and regeneration rate in nerves of streptozotocin-diabetic rats, Exp Neurol. 69:74–84 (1980).PubMedCrossRefGoogle Scholar
  33. 33.
    J. Sjorberg and M. Kanje, Insulin-like growth factor (IGF-1) as a stimulator of regeneration in the freeze-injured rat sciatic nerve, Brain Res. 485:102–08 (1989).CrossRefGoogle Scholar
  34. 34.
    L.S. Phillips and H.S. Young, Nutrition and somatomedin. II. Serum somatomedin activity in streptozotocin-diabetic rats, Diabetes. 25:516–27 (1976).PubMedCrossRefGoogle Scholar
  35. 35.
    M. Maes, I.M. Ketelslegers, and L.E. Underwood, Low plasma somatomedin-C in streptozotocin induced diabetes: correlation with changes in somatogenic and lactogenic liver binding sites, Diabetes. 32:1060–69 (1983 ).PubMedCrossRefGoogle Scholar
  36. 36.
    P.A.R. Ekstrom, M. Kanje and A. Skottner, Nerve regeneration and serum levels of insulin-like rwth factor-I in rats with streptozotocin-induced insulm deficiency, Brain Res. 496:141–47 (1989).PubMedCrossRefGoogle Scholar
  37. 37.
    M. Kanje, A. Skottner, J. Sjoberg and G. Lundborg, Insulin-like growth factor I (IGF-I) stimulates regeneration of the rat sciatic nerve, Brain Res. 486:396–98 (1989).PubMedCrossRefGoogle Scholar
  38. 38.
    F.A. McMorris, R.W. Furianetto, R.L. Mozell, M.J. Carson, and D.W. Raible, Regulation of oligodendrocyte development by insulin-like growth factors and cyclic nucleotides, Ann N Y Acad Sci. 101–09 (1990).Google Scholar
  39. 39.
    F.A. McMorris and M. Dubois-Dalcq, Insulin-like growth factor I promotes cell proliferation and oligodendroglial commitment in rat glial progenitor cells developing in vitro, J Neurosci Res. 21:199–209 (1988).PubMedCrossRefGoogle Scholar
  40. 40.
    R.H.M. van der Pal, J.W. Koper, L.M.G. van Golde, and M. Lopes-Cardozo, Effects of insulin and insulinlike growth factor (IOF-I) on oligodendrocyte-enriched glial cultures, J Neurosci Res. 19:483–90 (1988).PubMedCrossRefGoogle Scholar
  41. 41.
    R.P. Saneto, K.G. Low, M.H. Meiner, and J. de Vellis, Insulin/insulin-like growth factor I and other epigenetic modulators of myelin basic protein expression in isolated oligodendrocyte progenitor cells, J Neurosci Res. 21:210–19 (1988).PubMedCrossRefGoogle Scholar
  42. 42.
    E. Recio-Pinto, F.F. Lang and D.N. Ishii, Insulin and insulin-like growth factor II permit nerve growth factor binding and neurite formation response in cultured human neuroblastoma cells, Proc Natl Acad Sci USA. 81:2562–66 (1984).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  1. 1.Departments of Internal Medicine and PhysiologyEastern Virginia Medical SchoolNorfolkUSA
  2. 2.Department of Veterans Affairs Medical CenterEastern Virginia Medical SchoolHamptonUSA

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