Abstract
The insulin-like growth factors (IGF-I and IGF-II) are mitogenic pep tides that are structurally related to insulin (Figure 1). Until recently, these growth factors were thought to be produced exclusively by the liver and to act solely in an endocrine manner.1-3 According to the “somatomedin hypothesis,” the synthesis of IGF-I by the liver and its secretion are regulated by growth hormone (GH) and, following its release into the circulation, IGF-I reaches its target tissues where it induces growth and development, thereby mediating the effect of GH during the growth period.
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LeRoith, D., Werner, H., Burguera, B., Roberts, C.T., Mulroney, S., Haramati, A. (1992). The Insulin-Like Growth Factor Family of Peptides, Binding Proteins and Receptors: Their Potential Role in Tissue Regeneration. In: Vinik, A.I., Sirman, D.J. (eds) Pancreatic Islet Cell Regeneration and Growth. Advances in Experimental Medicine and Biology, vol 321. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3448-8_3
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DOI: https://doi.org/10.1007/978-1-4615-3448-8_3
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