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Human Mast Cells, Basophils and Their Mediators

  • Chapter
Asthma Treatment

Part of the book series: NATO ASI Series ((NSSA,volume 229))

Abstract

Over 100 years ago Paul Ehrlich identified mast cells in human connective tissues on the basis of the metachromatic staining properties of their prominent cytoplasmic granules [Ehrlich, 1878]. He also described the basophil, a circulating leukocyte containing cytoplasmic granules with staining properties similar to mast cells [Ehrlich, 1879]. Mast cells and basophils share several other notable features. They are among the few cell types that synthesize histamine and other chemical mediators implicated in the pathophysiology of a variety of inflammatory and immunological disorders [Marone, 1985; Marone et al.,1988; 1989a]. Both cell types also express plasma membrane receptors (FcεRI) that bind the Fc portion of IgE antibody with high affinity [Rossi et al., 1990].

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Authors and Affiliations

  1. Division of Clinical Immunology, Second School of Medicine, University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy

    Vincenzo Casolaro, Cristiana Stellato, Gennaro de Crescenzo, Massimo Triggiani & Gianni Marone

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  1. Vincenzo Casolaro
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  2. Cristiana Stellato
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  3. Gennaro de Crescenzo
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  4. Massimo Triggiani
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  5. Gianni Marone
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Editors and Affiliations

  1. University of Parma, Parma, Italy

    D. Olivieri

  2. National Heart and Lung Institute, London, UK

    P. J. Barnes

  3. National Institutes of Health, Bethesda, Maryland, USA

    S. S. Hurd

  4. University of Milan, Milan, Italy

    G. C. Folco

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Casolaro, V., Stellato, C., de Crescenzo, G., Triggiani, M., Marone, G. (1992). Human Mast Cells, Basophils and Their Mediators. In: Olivieri, D., Barnes, P.J., Hurd, S.S., Folco, G.C. (eds) Asthma Treatment. NATO ASI Series, vol 229. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3446-4_5

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