Skip to main content
SpringerLink
Log in

Osmotic and Ionic Factors in Bronchial Responsiveness

  • Chapter
Asthma Treatment

Part of the book series: NATO ASI Series ((NSSA,volume 229))

  • 147 Accesses

Abstract

Tracheo-bronchial epithelial cells are capable of active ion transport processes through which they can regulate both the amount and osmolarity of the periciliary and intercellular fluid (1-4). These variables can play an important role in modulating bronchial responsiveness, particularly in response to provoking agents acting through an osmolar mechanism, such as ultrasonically nebulized hypotonic and hypertonic solutions, exercise, and hyperventilation (5-9).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Al-Bazzaz FJ. Regulation of salt and water transport across airway mucosa. Clinics in Chest Medicine 1986; 7:259–272

    Google Scholar 

  2. Welsh MJ. Mechanisms of airway epithelial ion transport. Clinics in Chest Medicine 1986; 7:273–293

    PubMed  CAS  Google Scholar 

  3. Knowles M, Murray G, Shallal J, Askin F, Ranga V, Gatzy J, Boucher R. Bioelectric properties and ion flow across excised human bronchi. J Appl Physiol Respirat Environ Exercise Physiol 1984; 56:868–877

    CAS  Google Scholar 

  4. Widdicombe JH. Ion transport by tracheal cells in culture. Clinics in Chest Medicine 1986; 7:299–305

    PubMed  CAS  Google Scholar 

  5. Allegra L, Bianco S. Non-specific broncho-reactivity obtained with an ultrasonic aerosol of distilled water. Eur J Respir Dis 1980; 61(suppl): 41–49

    Google Scholar 

  6. Bianco S. Bronchial hyperractivity in response to inhalation of ultrasonically nebulized solutions of distilled water and saline. Br Med J. 1982; 417:284

    Google Scholar 

  7. Eschenbacher WL, Boushey HA, Sheppard D. Alteration in osmolarity of inhaled aerosols cause bronchoconstriction and cough, but absence of a permeant anion causes cough alone. Am Rev Respir Dis 1984; 129:211–215

    PubMed  CAS  Google Scholar 

  8. Smith CM, Anderson SD, Walsh S, Mcdrea MS. An investigation on the effects of heat and water exchange in the ricovery period after exercise in children with asthma. Am Rev Respir Dis 1989, 140:598–605.

    PubMed  CAS  Google Scholar 

  9. Bianco S, Robuschi M, Sestini P, Vaghi A, Refini RM, Pieroni MG, Gambaro G, Spagnotto S, Rossoni G, Berti F, and Pasargiklian M. Osmolarity, bronchial reactivity, and the protective effect of loop diuretics. In: G Melillo, PS Norman, G Marone eds, Respiratory Allergy, BC Decker publ, Toronto 1990, p 119–130

    Google Scholar 

  10. Jacoby DB, Ueki IF, Widdicombe JH, Loegering DA, Gleich GJ, Nadel JA. Effect of human eosinophil major basic protein on ion transport in dog tracheal epithelium. Am Rev Respir Dis 1988; 137:13–16

    Article  PubMed  CAS  Google Scholar 

  11. Tamaoki J, Ueki IF, Widdicombe JH, Nadel JA. Stimulation of C1-secretion by neurokinin A and neurokinin B in canine tracheal epithelium. Am Rev Respir Dis 1988; 137:899–902

    PubMed  CAS  Google Scholar 

  12. P Sestini, J Bienenstock, SE Crowe, JS Marshall, RH Stead, Y Kakuta, MH Perdue. Ion transport in rat epithelium in vitro: role of capsaicin-sensitive nerves in allergic reactions. Am Rev Respir Dis 1990, 393–397

    Google Scholar 

  13. Newman SP. Therapeutic aerosols. In: SW Clarke and D Pavia eds, Aerosols and the lung. Butterworths ed, London 1984, p. 197–224

    Google Scholar 

  14. Damonte C, Benetti T, Bianco S. Il riscaldamento a 32–37°C non modifica la reazione ostruttiva alla nebbia ultrasonica di H2O. Rass Patol App Respir 1987; 2(suppl):15

    Google Scholar 

  15. Lowry RH, Wood AM, Higenbottam TW. Effects of pH and osmolarity on aerosol-induced cough in normal volunteers. Clin Sci 1988; 74:373–376

    PubMed  CAS  Google Scholar 

  16. Shaw RJ, Anderson SD, Durhm SR, Taylor KM, Schoeffel RE, Green W, Torzillo P, Kay AB. Mediators of hypersensivity and “fog” induced asthma. Allergy 1985; 40:48–57

    Article  PubMed  CAS  Google Scholar 

  17. Moscato G, Rampulla C, Dellabianca A, Dorigo N, Majani V, Corsico R, Sirtori PG. Increased neutrophil chemotactic activity in exercise and “fog” induced asthma. Allergy 1987; 45:581–587

    Google Scholar 

  18. Black JL, Schoeffel RE, Sundrum R, Berend N, Anderson SD. Increased responsiveness to methacholine and histamine after challenge with ultrasonically nebulized water in asthmatic subjects. Thorax 1985; 40:427–432

    Article  PubMed  CAS  Google Scholar 

  19. Mattoli S, Foresi A, Corbo GM, Valente S, Patalano F, Ciappi G. Increase in bronchial responsiveness to methacholine and late asthmatic response after inhalation of ultrasonically nebulized distilled water. Chest 1986; 9:726–732

    Article  Google Scholar 

  20. Robuschi M, Gambaro G, Spagnotto S, Vaghi A, Bianco S. Inhaled furosemide (F) is highly effective in preventing ultrasonically nebulized water (UNH2O) bronchoconstriction. Pulmonary Pharmacology 1989, 1:187–191

    Article  PubMed  CAS  Google Scholar 

  21. Vaghi A. Robuschi M, Berni F, Bianco S. Attività antireattiva della furosemide somministrata per via inalatoria. Rass Patol Appar Respir 1989, 4(suppl 1):90

    Google Scholar 

  22. Bianco S, Vaghi A, Robuschi M. Furosemide: a “new” antireactive agent. It works only by inhalation. 23rd annual meeting SEPCR, Athens 1988, books of abstracts p 2s

    Google Scholar 

  23. Sestini P, Pieroni MG, Refini RM, Ferretti B, Civai R, Beltrami V, Bianco S. Effect of inhaled furosemide on respiratory function parameters of patients with reversible airway obstruction.In: New trends on pneumology and cardiology“. D. Olivieri ed., Monduzzi, Bologna 1990, p 55–59

    Google Scholar 

  24. Bianco S, Robuschi M, Vaghi A, Pieroni MG, Refini RM, Sestini P. Protective effect of inhaled piretanide on the bronchial obstructive response to ultrasonically nebulized H2O. Am Rev Respir Dis 1991, 143:A210

    Google Scholar 

  25. Vaghi A, Robuschi M, Sestini P, Gambaro G, Spagnotto S, Bianco S. Comparison of inhaled furosemide and bumetanide in preventing ultrasonically nebulized water bronchoconstriction. Eur Respir J 1990 3(suppl 10):93s

    Google Scholar 

  26. Robuschi M, Vaghi A, Gambaro G, Spagnotto S, Bianco S. Inhaled furosemide (F) is effective in preventing ultrasonically nebulized 5.8% NaC1 bronchoconstriction. Eur Respir J 1988, 1(suppl 1):193s.

    Google Scholar 

  27. Moscato G, Dellabianca A, Falagiani P, Mistrello G, Rossi GL, Rampulla C. Inhaled furosemide prevents both the bronchoconstriction and the increase in neutrophil chemiotactic activity induced by ultrasonic “fog” of distilled water in asthmatics. Am Rev Respir Dis 1989, 139(suppl):A327

    Google Scholar 

  28. Finnerty JP, Wilnot C, Holgate ST. Inhibition of hypertonic saline-induced bronchoconstriction by terfenadine and flurbiprofen. Am Rev Respir Dis 1989, 140:593–597

    PubMed  CAS  Google Scholar 

  29. Bianco S, Vaghi A, Robuschi M, Pasargiklian M. Prevention of exercise-induced bronchoconstriction by inhaled frusemide. Lancet 1988; ii: 252–5

    Article  Google Scholar 

  30. Vaghi A, Berni F, Robuschi M, Sestini P, Bianco S. Indomethacin (I) does not influence the protective effect of furosemide (F) against exercise-induced bronchoconstriction. Eur Respir J 2(suppl 8):790

    Google Scholar 

  31. Wilkens JH, Wilkens H, Nieger M, Duft S, Frölich JC, Fabel H, Sybrecht GW. Effects of inhaled lysine acetylsalicylic acid and furosemide on exercise induced asthma. Am Rev Respir Dis 1991, 143:A548

    Google Scholar 

  32. Vaghi A, Robuschi M, Chilaris N, Bianco S. Inhaled furosemide (F) does not attenuate the bronchial response to methacoline (M) in asthmatics. 23rd annual meeting SEPCR, Athens 1988, books of abstracts p 8s

    Google Scholar 

  33. Vaghi A, Robuschi M, Berni F, Bianco S. Effect of inhaled furosemide (F) on bronchial response to histamine (H) in asthmatics. 23rd annual meeting SEPCR, Athens 1988, books of abstracts p 406s

    Google Scholar 

  34. Yauha MA, Loring SH, Ingram RH Jr, Drazen JM. Direct and reflex bronchoconstriction induced by histamine aerosol inhalation in dogs. J Appl Physiol Respir Environ Exercise Physiol 1981, 50:869–879

    Google Scholar 

  35. Nichol GN, Alton EWFW, Nix A, Geddes DM, Chung KF, Barnes PJ. Effect of inhaled furosemide on metabisulfite-and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects. Am Rev Respir Dis 1990, 142:576–580

    Article  PubMed  CAS  Google Scholar 

  36. Grubbe RE, Hopp R, Dave NK, Brennan B, Bewtra A, Townley R. Effect of inhaled furosemide on the bronchial response to methacholine and cold-air hyperventilation challenges. J Allergy Clin Immunol 1990, 85:881–884

    Article  PubMed  CAS  Google Scholar 

  37. Polosa R, Leu LC, Holgate St. Inhibition of adenosine 5’- monophosphate-and methacholine-induced bronchoconstriction in asthma by inhaled furosemide. Eur Respir J 1990, 3:665–672.

    PubMed  CAS  Google Scholar 

  38. Bianco S, Pieroni M, Refini M, Sturman A, Robuschi M. Inhaled furosemide (F) prevents allergen induced bronchoconstriction in atopic asthmatics. Am Rev Respir Dis 1988 (abstract); 137:27

    Google Scholar 

  39. Robuschi M, Pieroni M, Refini M, Bianco S, Rossoni G, Magni F, Berti F. Prevention of antigen induced early obstructive reaction by inhaled furosemide in (atopic) asthmatics and (actively sensitized) guinea pigs. J Allergy Clin Immunol 1990; 85:10–16

    Article  PubMed  CAS  Google Scholar 

  40. Verdiani P, Di Carlo S, Baronti A, Bianco S: Effect of inhaled frusemide on the early response to antigen and subsequent change in airway reactivity in atopic patients. Thorax 1990, 45:377–381

    Article  PubMed  CAS  Google Scholar 

  41. S Bianco, MG Pieroni, RM Refini, B Ferretti, V Beltrami, R Civai, P Sestini. Attenuation of the the bronchial response to allergen by inhalation of furosemide after allergen challenge. Am Rev Respir Dis 1990, 141:A474

    Google Scholar 

  42. Bianco S, Pieroni M, Refini M, Rottoli L, Sestini P. Protective effect of inhaled furosemide on allergen-induced early and late asthmatic reactions. N Engl J Med 1989, 321:1069–1073

    Article  PubMed  CAS  Google Scholar 

  43. O’Byrne PM, Dolovich J, Hargreave FE. Late asthmatic responses. Am Rev Respir Dis 1987; 136: 740–51

    Article  PubMed  Google Scholar 

  44. Rottoli L, Rottoli P, Sparnacci F, Bianco S. In vitro effect of furosemide on O2 production. Eur Resp J 1989, 2(suppl 8): 861s.

    Google Scholar 

  45. Anderson SD, Wei H, Temple DM. Inhibition by furosemide of inflammatory mediators from lung fragments. N Engl J Med 1991, 324:131

    PubMed  CAS  Google Scholar 

  46. Elwood W, Lotvall JO, Barnes P, Chung KF. Loop diuretics inhibit cholinergic and noncholinergic nerves in guinea pig. Amer Rev Respir Dis 1991, 143:1345–1349.

    Google Scholar 

  47. Robuschi M, Vaghi A, Pieroni MG, Sestini P, Bianco S. Aspirin but not sodium salicylate prevents fog-induced bronchoconstriction. Amer Rev Respir Dis 1991, 143:A423

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institutes of Cardiovascular and Respiratory Diseases, Italy

    Sebastiano Bianco

  2. Institutes of Respiratory Diseases, Italy

    Mariella Robuschi, Gabriella Gambaro & Stefano Spagnotto

  3. University of Milan, Hospital of Garbagnate, Milan, Italy

    Adriano Vaghi

  4. Institute of Respiratory Diseases, University of Siena, Italy

    Maria Grazia Pieroni, Rosa Metella Refini & Piersante Sestini

Authors
  1. Sebastiano Bianco
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mariella Robuschi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Adriano Vaghi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gabriella Gambaro
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Stefano Spagnotto
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Maria Grazia Pieroni
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Rosa Metella Refini
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Piersante Sestini
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Parma, Parma, Italy

    D. Olivieri

  2. National Heart and Lung Institute, London, UK

    P. J. Barnes

  3. National Institutes of Health, Bethesda, Maryland, USA

    S. S. Hurd

  4. University of Milan, Milan, Italy

    G. C. Folco

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer Science+Business Media New York

About this chapter

Cite this chapter

Bianco, S. et al. (1992). Osmotic and Ionic Factors in Bronchial Responsiveness. In: Olivieri, D., Barnes, P.J., Hurd, S.S., Folco, G.C. (eds) Asthma Treatment. NATO ASI Series, vol 229. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3446-4_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-3446-4_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6525-9

  • Online ISBN: 978-1-4615-3446-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation