Taurine pp 45-54 | Cite as

Intestinal Taurine and the Enterohepatic Circulation of Taurocholic Acid in the Cat

  • Mary Anne Hickman
  • James G. Morris
  • Quinton R. Rogers
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 315)

Abstract

Taurine’s most well defined role is the conjugation of bile salts in the liver. After synthesis from cholesterol, bile salts are conjugated with taurine and/or glycine before secretion into the bile canaliculi1. When taurine is limiting, most mammals have the ability to conjugate bile salts with glycine, exceptions being the dog2 and the cat3,4, which conjugate bile salts almost exclusively with taurine. The percentage of total bile salts conjugated with taurine is determined by both the hepatic taurine concentration and the affinity of the bile salt conjugase for glycine and taurine2,5-7. Taurine is the preferred substrate in most species with 90 percent taurine conjugation occurring in the rat when hepatic taurine and glycine concentrations are equal7. Hepatic taurine depletion in rats, caused by the infusion of cholic acid7 or by feeding guanidinoethanesulfonic acid5, results in a substantial increase in the amount of bile salts conjugated with glycine. In species that cannot conjugate bile salts with glycine (the dog and cat), hepatic taurine depletion leads instead to an increase in the proportion of unconjugated bile salts, the majority being free cholic acid2,3.

Keywords

Cholesterol Carbohydrate Glycine Retina Cardiomyopathy 

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References

  1. 1.
    W.H. Elliott, Metabolism of bile acids in liver and extrahepatic tissues, in: “Sterols and Bile Acids (New Comprehensive Biochemistry)”, H. Danielsson and J. Sjövall, eds., Elsevier, Amsterdam, pp. 303–329 (1985).CrossRefGoogle Scholar
  2. 2.
    E.R.L. O’Mádille, T.G. Richards, and A.H. Short, Acute taurine depletion and maximal rates of hepatic conjugation and secretion of cholic acid in the dog, J. Physiol. 180:67–79 (1965).Google Scholar
  3. 3.
    LA. Rentschler, L.L. Hirschberger, and M.H. Stipanuk, Response of the kitten to dietary taurine depletion: Effects on renal reabsorption, bile acid conjugation and activities of enzymes involved in taurine synthesis, Comp. Biochem. Physiol. 84B:319–325 (1986).Google Scholar
  4. 4.
    J.A. Sturman, D.K. Rassin, K.C. Hayes, and G. E. Guall, Taurine deficiency in the kitten: Exchange and turnover of [35S] taurine in brain, retina, and other tissues, J. Nutr. 108:1462–1476 (1978).Google Scholar
  5. 5.
    J. De La Rosa and M.H. Stipanuk, The effect of taurine depletion with guanidinoethanesulfonate on bile acid metabolism in the rat, Life Sci. 36:1347–1351 (1985).CrossRefGoogle Scholar
  6. 6.
    D.A. Vessey, The biochemical basis for the conjugation of bile acids with either glycine or taurine, Biochem. J. 174:621–626 (1978).Google Scholar
  7. 7.
    W.G.M. Hardison and J.H. Proffitt, Influence of hepatic taurine concentration on bile acid conjugation with taurine, Am. J. Physiol. 1:E75–E79 (1977).Google Scholar
  8. 8.
    J.R. Malagelada, V.L.W. Go, E.P. DiMagno, and W.H.J. Summerskill, Interactions between intraluminal bile acids and digestive products on pancreatic and gallbladder function, J. Clin. Invest. 52:2160–2165 (1973).CrossRefGoogle Scholar
  9. 9.
    G. Gomez, J.R. Upp, F. Lluis, R.W. Alexander, G.J. Poston, G.H. Greeley, Jr. and J.C. Thompson, Regulation of the release of cholecystokinin by bile salts in dogs and humans, Gastroenterology 94:1036–1046 (1988).Google Scholar
  10. 10.
    T. Midtvedt and A. Norman, Bile acid transformations by microbial strains belonging to genera found in intestinal contents, Acta Path. Microbiol. Scandinay. 71:629–638 (1967).CrossRefGoogle Scholar
  11. 11.
    G.W. Hepner, J.A. Sturman, A.F. Hofmann, and P.I. Thomas, Metabolism of steroid and amino acid moieties of conjugated bile acids in man. III. Choyltaurine (taurocholic acid), J. Clin. Invest. 52:443–440 (1973).CrossRefGoogle Scholar
  12. 12.
    M.W. Huff. and K.K. Carroll, Effects of dietary protein on turnover, oxidation, and absorption of cholesterol, and on steroid excretion in rabbits, J. Lipid Res. 21:546–558 (1980).Google Scholar
  13. 13.
    Y.-S. Choi, S. Goto, I. Ikeda, and M. Sugano, Interaction of dietary protein, cholesterol and age on lipid metabolism of the rat, Br. J. Nutr. 61:531–543 (1989).CrossRefGoogle Scholar
  14. 14.
    M. Sugano, S. Goto, Y. Yamada, K. Yoshida, Y. Hashimoto, T. Matsuo, and M. Kimoto, Cholesterol-lowering activity of various undigested fractions of soybean protein in rats, J. Nutr. 120:977–985 (1990).Google Scholar
  15. 15.
    S. Makin, H. Nakashima, K. Minami, R. Moriyama, and S. Takao, Bile acid-binding protein from soybean seed: Isolation, partial characterization and insulin-stimulating activity, Agric. Biol. Chem. 52:803–809 (1988).CrossRefGoogle Scholar
  16. 16.
    D. Kritchevsky and J.A. Story, Binding of bile salts in vitro by nonnutritive fiber, J. Nutr. 104:458–462 (1974).Google Scholar
  17. 17.
    E.W. Pomare, K.W. Heaton, T.S. Low-Beer, and H.J. Espiner, The effect of wheat bran upon bile salt metabolism and upon the lipid composition of bile in gallstone patients, Digestive Diseases 21:521–526 (1976).CrossRefGoogle Scholar
  18. 18.
    Y. Imai, S. Kawata, M. Inaoa, S. Miyoshi, Y. Minami, Y. Matsuzawa, K Uchioa, and S. Tarui, Effect of cholestyramine on bile acid metabolism in conventional rats, Lipids 22:513–516 (1987).CrossRefGoogle Scholar
  19. 19.
    K. Ebihara and B.O. Schneeman, Interaction of bile acids, phospholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats,J. Nutr. 119:1100–1106 (1989).Google Scholar
  20. 20.
    T. Ide and M. Horii, Predominant conjugation with glycine of biliary and lumen bile acids in rats fed on pectin, Br. J. Nutr. 61:545–557 (1988).CrossRefGoogle Scholar
  21. 21.
    T. Ide, K. Takashi, M. Horri, T. Yamamoto, and K Kawashima, Contrasting effects of water-soluble and water-insoluble dietary fibers on bile acid conjugation and taurine metabolism in the rat, Lipids 25:335–340 (1990).CrossRefGoogle Scholar
  22. 22.
    T. Ide, M. Horri, K. Kawashima, and T. Yamamoto, Bile acid conjugation and hepatic taurine concentration in rats fed on pectin, Br. J. Nuts. 62:539–550 (1989).CrossRefGoogle Scholar
  23. 23.
    P.D. Pion, M.D. Kittleson, Q.R. Rogers, and J.G. Morris, Myocardial failure in cats associated with low plasma taurine: A reversible cardiomyopathy, Science 237:764–768 (1987).CrossRefGoogle Scholar
  24. 24.
    J.G. Morris, Q.R. Rogers, and L.M. Pacioretty, Taurine: An essential nutrient for cats, J. Small Anirn. Pract. 31:502–509 (1990).CrossRefGoogle Scholar
  25. 25.
    J.A. Cooke, Q.R. Rogers, and J.G. Morris, Urinary and fecal excretion of taurine by cats fed commercial canned diets, FASEB J. 3:A1617 (1989).Google Scholar
  26. 26.
    K. Shiekh, Taurine deficiency and retinal defects associated with small intestine bacterial overgrowth, Gastroenterology 80:1363 (1981).Google Scholar
  27. 27.
    K. Ikeda, H. Yamada, and S. Tanaka, The bacterial degradation of taurine, J. Biochem. 54:312–316 (1963).Google Scholar
  28. 28.
    M.A. Hickman, Q.R. Rogers, and J.G. Morris, Effect of processing on fate of dietary [14C]taurine in cats, J. Nutr. 120:995–1000 (1990).Google Scholar
  29. 29.
    MA. Hickman, Q.R. Rogers, and J.G. Morris, Taurine balance is different in cats fed purified and commercial diets, J. Nutr., in press (1992).Google Scholar
  30. 30.
    S.L. Gorbach, Progress in gastroenterology, intestinal microflora, Gastroenterology 60:1110–1129 (1971).Google Scholar
  31. 31.
    MA. Hickman, M.L. Bruss, J.G. Morris, and Q.R. Rogers, Kinetics of the enterohepatic circulation of taurocholic acid are affected by dietary protein source, soybean versus casein, and taurine status in cats, J. Nutr., in press (1992).Google Scholar
  32. 32.
    S.D. Feighner and M.P. Dashkevicz, Effect of dietary carbohydrates on bacterial cholytaurine hydrolase in poultry intestinal homogenates, Appl. Environ. Micro. 54:337–342 (1988).Google Scholar
  33. 33.
    M. Winitz, R.F. Adams, D.A. Seedman, P.N. Davis, L.G. Jayko, and J.A. Hamilton, Studies in metabolic nutrition employing chemically defined diets, Am. J. Clin. Nuts. 23:546–559 (1970).Google Scholar
  34. 34.
    M.J. Hill and B.S. Drasar, Degradation of bile salts by human intestinal bacteria, Gut 9:22–27 (1968).CrossRefGoogle Scholar
  35. 35.
    S. Hayakawa, Microbiological transformation of bile acids, Adv. Lipid Res. 11:143–192 (1973).Google Scholar
  36. 36.
    T. Chikai, H. Nakao, and K. Uchida, Deconjugation of bile acids by human intestinal bacteria implanted in germ-free rats, Lipids 22:669–671 (1987).CrossRefGoogle Scholar
  37. 37.
    B.E. Gustafsson, S. Bergstsröm, S. Lindstedt, and A. Norman, Turnover and nature of fecal bile acids in germfree and infected rats fed cholic acid-24-14C, Proc. Soc. Exp. Biol. Med. 94:467–471 (1957).Google Scholar
  38. 38.
    S. Borgström, L. Krabisch, M. Lindstrom, and J. Lillienau, Deconjugation of bile salts: Does it occur outside the contents of the intestinal tract in the rat?, Scand. J. Clin. Lab. Invest. 47:543–549 (1987).Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Mary Anne Hickman
    • 1
  • James G. Morris
    • 1
  • Quinton R. Rogers
    • 1
  1. 1.Department of Physiological Sciences School of Veterinary MedicineUniversity of CaliforniaDavisUSA

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