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Taurine pp 399-404 | Cite as

Potassium-Stimulated Release of Taurine in a Crude Retinal Preparation Obtained from the Rat is Calcium Independent

  • John B. Lombardini
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 315)

Abstract

The role of taurine as a potential neurotransmitter in the retina has been questioned in numerous literature reports. Thus, crude retinal homogenates prepared from rat retina were preloaded with [3H]taurine under either high-or low-affinity uptake conditions and were then subjected to superfusion techniques to determine whether KC1 (56 mM), veratridine (100 μM), 4-aminopyridine (1 mM), or LiC1 (56 mM3) could evoke the release of [3H]taurine. Dependence of the K+-evoked release of [3H]taurine on Ca2+ was also measured since one of the essential criteria for a neurotransmitter is Ca2+-dependent release of the substance from presynaptic nerve terminals.

Keywords

Lithium Chloride Scorpion Venom Cortex Slice Taurine Release Presynaptic Nerve Terminal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • John B. Lombardini
    • 1
  1. 1.Departments of Pharmacology and Ophthalmology & Visual SciencesTexas Tech University Health Sciences CenterLubbockUSA

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