Advertisement

Taurine pp 319-328 | Cite as

Taurine Protection of Lungs in Hamster Models of Oxidant Injury: A Morphologic Time Study of Paraquat and Bleomycin Treatment

  • Ronald E. Gordon
  • Richard F. Heller
  • Rachel F. Heller
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 315)

Abstract

The intracellular reduction of oxygen is a natural part of nutrient conversion into energy and results in the production of small amounts of short-lived intermediates of oxygen; superoxide [O2-], singlet oxygen [1O2],hydrogen peroxide [H2O2] and hydroxide radical [OH]1. Naturally occurring enzymatic “scavengers” serve as the primary protection against oxidant injury2. When the production of oxygen intermediates exceeds the scavenging and detoxifying capacity of these enzymes, then lung parenchymal cell injury results3.

Keywords

Pulmonary Fibrosis Interstitial Fibrosis Light Micrograph Intratracheal Instillation Taurine Supplementation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    I. Fridovich, The biology of oxygen radicals, Sci. 201:875–880 (1978).CrossRefGoogle Scholar
  2. 2.
    J.M. McCord, The biology and pathology of oxygen radicals, Ann. Intern. Med. 898:12–127 (1978).Google Scholar
  3. 3.
    M.S. Rose, L.L. Smith, and L. Wyatt, Evidence for energy-dependent accumulation of paraquat in rat lung, Nature (London) 252:314–315 (1974).CrossRefGoogle Scholar
  4. 4.
    M. Luna, C. Bedrossian, L. Lichtiger, and PA. Salem, Interstitial pneumonitis associated with bleomycin therapy, Am. J. Clin. Pathol. 58:501–510 (1974).Google Scholar
  5. 5.
    G.L. Snider, B.R. Celli, R.H. Goldstein, J.J. O’Brien, E.C. Lucy, Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal blemoycin, Am. Rev. Respir. Dis. 1170–289–297.Google Scholar
  6. 6.
    G.L. Snider, JA. Hayes, a.L. Kortly, Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal bleomycin: Pathology and stereology, Am. Rev. Respir. Dis. 117:1099–1108.Google Scholar
  7. 7.
    J.E. Zuckerman, J.E.MA. Hollinger, S.N. Giri, Evaluation of antibiotic drugs in bleomycin-induced pulmonary fibrosis in hamsters, J. Pharmacol. Exp. Titer. 213:425–431 (1980).Google Scholar
  8. 8.
    EA. Sausville, K. Peisach, S.B. Horowitz, Effect of chelating agents and metal ions on the degradation of DNA by bleomycin, Biochem. 17:2740–2746 (1978).CrossRefGoogle Scholar
  9. 9.
    H. Ekimoto, H. H. Kuramochi, K. Takahashi, A. Matsuda, H. Umezawa, Kinetics of the ration of bleomycin-Fe(II)-O2 complex with DNA, J. Antibiot. (Tokyo); 33:426–434 (1980).CrossRefGoogle Scholar
  10. 10.
    J.M.C. Gutteridge, T. Xiai-Chang, Protection of iron-catalyzed free radical damage to DNA and lipids by copper (II)-bleomycin, Biochem. Biophys. Res. Commun. 99:1354–1360 (1981).CrossRefGoogle Scholar
  11. 11.
    D.B. Chandler, D.M. Hyde, S.N. Giri, Morphometric estimates of infiltrative cellular changes during the development of bleomycin-induced pulmonary fibrosis in hamsters, Am. J. pathol. 112–170–177 (1983).Google Scholar
  12. 12.
    R.S. Thrall, R.W. Barton, a comarison of lymphocyte populations in lung tissue and in bronchiolar lavage fluid of rats at various times during the development of bleomycin-induced pulmonary fibrosis, Am. Rev. Respir. Dis. 129: 279–283.Google Scholar
  13. 13.
    J.E. Bus and J.E. Gison, Paraquat: Model of oxidant-initiated toxicity, Environ. Health Perspectives 55:37–46 (1984).CrossRefGoogle Scholar
  14. 14.
    M.S. Rose, E.L. Lock, L.L. Smith, and L. Wyatt, Paraquat accumulation: tissue and species specificity, Biochem. PharmacoL 25:419–423 (1976).CrossRefGoogle Scholar
  15. 15.
    L.L. Smith, M.S. Rose, I. Wyatt, The pathology and biochemistry of paraquat, CIBA Found Symp. 65:321–341 (1978).Google Scholar
  16. 16.
    D.J.P. Bassett and A.B. Fisher, Alterations of glucose metabolism during perfusion of rat lung with paraquat, Am. J. Physiol. 234(6):E653–E659 (1978).Google Scholar
  17. 17.
    J.G. Alvarez and B.T. Storey, Taurine, hypotaurine and albumin inhibit lipid peroxidation in rabbit spermatozoa and protect against loss of motility, Biol. Reprod. 291:548–555 (1983).CrossRefGoogle Scholar
  18. 18.
    M.J. McBroom and J.D. Welty, Comparision of taurine-verapamil interaction in hamsters and rats, Comp. Biochem. Physiol. 80C(2):217–219 (1985).Google Scholar
  19. 19.
    T. Nakashima, T. Takino, and K. Kuriyama, Therapeutic and prophylactic effects of taurine administration on experimental liver injury, in:“Sulfur Amino Acids: Biochemical and Clinical Aspects,” K. Kuriyama, R.J. Huxtable, and H. Iwata, eds., pp. 449–459, Alan R. Liss Inc. NY (1985).Google Scholar
  20. 20.
    C.E. Wright, T.T. Lin, Y.Y. Lin, JA. Sturman, and G.E. Gaull, Taurine scavengers oxidized chlorine in biological systems, in:“Taurine: Biologial Actions and Chemical Perspectives,” S.S. Oja, L. Ahtee, P. Kontrol, and M.K. Paasonen, eds., pp. 137–147, Alan R. Liss Inc., NY (1985).Google Scholar
  21. 21.
    R.J. Huxtable, H.E. Laird, and S.E. Lippincott, The transport of taurine in the heart and the rapid depletion of tissue taurine by guanidinoethyl sulfonate, J. Pharmac. Exp. Ther. 211:465–471 (1979).Google Scholar
  22. 22.
    J.D. Welty and M.J. McBroom, Effects of taurine and verapamil on heart calcium in normal (Fitt) and cardiomyopathic (BIO 14.6) hamsters, Fedn. Proc. Fedn. Am. Soc. Exp. Biol. 41:1524 (1982).Google Scholar
  23. 23.
    C.W.N. Bedrossian, MA. Luna, B. MacKay, and B. Lichtiger, Ultrastructure of pulmonary bleomycintoxicity, Cancer 32:44–51.Google Scholar
  24. 24.
    H.F. Krous and W.B. Hanlin, Pulmonary toxicity due to bleomycin, Arch. FathoL 95:407–410 (1973).Google Scholar
  25. 25.
    S.N. Giri, D.M. Hyde, and B.J. Marafio, Ameliorating effect of murine interferon gamma on bleomycin-induced lung collagen fibrosis in mice, Biochem. Med. Metab. Biol. 36:194–197.Google Scholar
  26. 26.
    D.B. Chandler, T.W. Butler, D.D. Brigs III, W.E. Grizzle, J.C. Barton, and J.D. Fuller, Modulation of the development of bleomycin-induced fibrosis by deferoxamine, Toxicol. Appl. Pharmacol. 92:358–367 (1988).CrossRefGoogle Scholar
  27. 27.
    S.N. Giri, Z. Chen, W.R. Younker, and M.J. Schmidt, Effects of intratracheal administration of bleomycin on GSH-shuttle enzymes, catalase, lipid peroxidation and collagen content in the lungs of hamsters, Toxicol. Appl. Pharmacol. 71:132–141 (1983).CrossRefGoogle Scholar
  28. 28.
    S.N. Giri, D.M. Hyde, and J.M. Nakashima, Analysis of bronchiolar lavage fluid from bleomycininduced pulmonary fibrosis in hamsters, ToxicoL Pathol. 14:149–157 (1986).CrossRefGoogle Scholar
  29. 29.
    S.N. Giri, J.M. Nakashima, and D.L. Curry, Effects of intratracheal administration of bleomycin or saline in pair-fed and control-fed hamsters on daily food intake and on plasma levels of glucose, ToxicoL PathoL 15:163–172.Google Scholar
  30. 30.
    D.J. Schreier and S.H. Phan, Modulation of bleomycin-induced pulmonary fibrosis in the BALB/c mouse by cyclophosphamide-sensitive T cells, Am. J. PathoL 116:270–278 (1984).Google Scholar
  31. 31.
    J.M. Nakashima, D.M. Hyde, and S.N. Giri, Effects of a calmodulin inhibitor on bleomycin-induced lung inflammation in hamsters, Biochemical morphometric and bronchio-alveolar lavage data, Am. J. PathoL 124:528–536 (1986).Google Scholar
  32. 32.
    P. Smith, D Heath, and J.M. Kay, The patholgenesis and development of paraquat-induced pulmonary fibrosis in rats, J. Path. 114:57–67 (1974).CrossRefGoogle Scholar
  33. 33.
    T.K. Aldrich, A.B. Fisher, E. Cadenas, and B. Chance, Evidence for lipid peroxidation by paraquat in the perfused rat lung, J. Lab. Clin. Med. 101:66–73 (1983).Google Scholar
  34. 34.
    Q. Wang, S.N. Giri, D.M. Hyde, and J.M. Nakashima, Effects of taurine on bleomycin-induced lung fibrosis in hamsters, Proc. Soc. Exper. BioL Med. 190:330–338 (1989).Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Ronald E. Gordon
    • 1
  • Richard F. Heller
    • 1
  • Rachel F. Heller
    • 1
  1. 1.Department of Pathology - Box 1194Mount Sinai School of MedicineNew YorkUSA

Personalised recommendations