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Taurine pp 295–301Cite as

Endogenous Regulation of the Taurine Receptor

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 315))

Abstract

Recently we have isolated and purified an endogenous brain modulator (EBM) which competes with 3H-flunitrazepam (FNZP) for binding to the benzodiazepine (BZ) binding site1. In addition, we have also isolated and purified EBMs for the GABAA receptor as well as the glutamate receptor2. In light of numerous lines of evidence suggesting that taurine is involved in many important physiological functions such as in the development of the CNS3,4 in maintaining the structural integrity of the membrane5,6, in regulating calcium binding and transport7,8 and serving as an osmoregulator9,10 and inhibitory neurotransmitter11,13, it is highly desirable to determine whether endogenous modulators are also involved in the regulation of the taurine receptor. In this communication we present evidence to show that the taurine receptor is indeed also regulated by EBMs.

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References

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Authors and Affiliations

  1. Department of Physiology and Cell Biology, University of Kansas, Lawrence, KS, 66045, USA

    X. W. Tang, Y. H. Lee, M. Yarom, B. Nathan, J. Baol, A. Bhattacharyya & J.-Y. Wu

  2. Academia Sinica, Taipei, Taiwan, ROC

    W. H. Tsai & J.-Y. Wu

Authors
  1. X. W. Tang
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  2. Y. H. Lee
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  3. M. Yarom
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  4. B. Nathan
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  5. J. Baol
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  6. A. Bhattacharyya
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  7. W. H. Tsai
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  8. J.-Y. Wu
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Editor information

Editors and Affiliations

  1. Texas Tech University Health Sciences Center, Lubbock, Texas, USA

    John B. Lombardini

  2. University of South Alabama School of Medicine, Mobile, Alabama, USA

    Stephen W. Schaffer

  3. Osaka University Medical School, Osaka, Japan

    Junichi Azuma

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© 1992 Springer Science+Business Media New York

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Tang, X.W. et al. (1992). Endogenous Regulation of the Taurine Receptor. In: Lombardini, J.B., Schaffer, S.W., Azuma, J. (eds) Taurine. Advances in Experimental Medicine and Biology, vol 315. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3436-5_35

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  • DOI: https://doi.org/10.1007/978-1-4615-3436-5_35

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6520-4

  • Online ISBN: 978-1-4615-3436-5

  • eBook Packages: Springer Book Archive

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