Abstract
The advent of acquired immunodeficiency syndrome has ushered in a renaissance in the field of antiviral research. Many compounds possessing inhibitory activity against different viruses have been described. New drugs such as azidothymidine have been added to the limited arsenal of licensed antiviral agents but serious side effects associated with many preparations have restricted their widespread use. In an effort to reduce adverse reactions, combination regimens consisting of antiviral drugs and synergistically acting immunomodulators are being increasingly investigated.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
T. A. Bektimirov, Current status of amantadine and rimantadine as anti-influenza-A agents, Bull. Wld. Hlth. Org. 63: 51 (1985).
D. B. Calne, The role of various forms of treatment in the management of Parkinson’s disease, Clin. Neuropharmacol. 5(suppl.1):38 (1982).
D. A. Fisher, Recurrent herpes simplex sciatica and its treatment with amantadine hydrochloride, Cutis 29:467 (1982).
A. W. Galbraith, Prevention of post-herpetic neuralgia by amantadine hydrochloride, Br. J. C1in. Pract. 37:304 (1983).
W. C. Koff, J. L. Jr. Elm, and S. B. Halstead, Inhibition of dengue virus replication by amantadine hydrochloride, Antimicrob. Agents Chemother. 18:125 (1980).
A. Helenius, M. Marsh, and J. White, Inhibition of Semliki Forest virus penetration by lysosmotropic weak bases, J. Gen. Virol. 58:47 (1982).
R. Schlegel, R. B. Dickson, M. C. Willingham, and I. H. Pastan, Amantadine and dansylcadaverine inhibit vesicular stomatitis virus uptake and receptor-mediated endocytosis of alpha 2-macroglobulin, Proc. Natl. Acad. Sci. USA 79:2291 (1982).
A. Widell, B. G. Hansson, B. Oberg, and E. Nordenfelt, Influence of twenty potentially antiviral substances on in vitro multiplication of hepatitis A virus, Antiviral Res. 6:103 (1986).
K. N. Masihi, W. Brehmer, W. Lange, and E. Ribi, Effects of mycobacterial fractions and muramyl dipeptide on the resistance of mice to aerogenic influenza virus infection, Int. J. Immunopharmac. 5:403 (1983).
F. X. Dietrich, H. K. Hochkeppel, and B. Lukas, Enhancement of host resistance against virus infections by MTP-PE, a synthetic lipophilic muramyl peptide. 1.Increased survival in mice and guinea pigs after single drug administration prior to infection, and the effect of MTP-PE on interferon levels in sera and lungs, Int. J. Immunopharm. 8:931 (1986).
K. N. Masihi, W. Lange, and B. Rohde-Schulz, Stimulation of antiviral activity by immunomodulators, in: “Antiviral Drugs, Basic and Therapeutic Aspects,” R. Calio and G. Nistico, eds., Pythagora Press, Rome (1989).
S. Ikeda, T. Negishi, and C. Nishimura, Enhancement of nonspecific resistance to viral infection by muramyl dipeptide and its analogs, Antiviral Res. 5:207 (1985).
I. Azuma, J. Iida, K. Nishimura, C. Ishihara, S. Tokura, and Y. Yamamura, Prevention of Sendai virus infection with synthetic MDP and chitin derivatives in mice, in: “Immunomodulators and Nonspecific Host Defence Mechanisms Against Microbial Infections,” K. N. Masihi and W. Lange, eds., Pergamon Press, Oxford (1988).
C. X. George, R. K. Jain, C. M. Gupta, and N. Anand, Enhancement in anti-Semliki Forest virus activity of ds RNA by muramyl dipeptide, FEBS. 200:37 (1986).
K. Masek, J. Seifert, M. Flegel, M. Krojidlo, and J. Kolinsky, The immunomodu-latory property of a novel synthetic compound adamantylamide dipeptide, Meth. Find. Exptl. Clin. Pharmacol. 6:667 (1984).
K. N. Masihi, W. Lange, B. Rohde-Schulz, and K. Masek, Antiviral activity of immunomodulator adamantylamide dipeptide, Int. J. Immunotherapy 111:89 (1987).
K. N. Masihi, W. Lange, S. Schwenke, G. Gast, P. Huchshorn, A. Palache, and K. Masek, Effect of immunomodulator adamantylamide dipeptide on antibody response to influenza subunit vaccines and protection against aerosol influenza infection, Vaccine 8:159 (1990).
A. Borecki and K. N. Masihi, Immunomodulatory effects of influenza subunit vaccine adjuvantized with adamantylamide dipeptide (AdDP) or its constituent components, in: “Immunotherapeutic Prospects of Infectious Diseases,” K. N. Masihi and W. Lange, eds., Springer Verlag, Berlin (1990).
F. Y. Liew, S. M. Rüssel, G. Appleyard, C. M. Brand, and J. Beale, Cross-protection in mice infected with influenza A virus by the respiratory route is correlated with local IgA antibody rather than serum antibody or cytotoxic T cell reactivity, Eur. J. Immunol. 14:350 (1984).
R. G. Webster and B. A. Askonas, Cross-protection and cross-reactive cytotoxic T cells induced by influenza virus vaccines in mice, Eur. J. Immunol. 10:396 (1980).
K. L. Yap, G. L. Ada, and I. F. C. McKenzie, Transfer of specific cytotoxic T-lymphocytes protects mice inoculated with influenza virus, Nature 273:238 (1978).
A. E. Lukacher, V. L. Braciale, and T. J. Braciale, In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific, J. Exp. Med. 160:814 (1984).
P. M. Taylor and B. A. Askonas, Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo, Immunology 58:417 (1986).
R. M. Kris, R. Asofsky, C. B. Evans, and P. A. Small, Protection and recovery in influenza virus-infected mice immunsuppressed with anti-IgM, J. Immunol. 134:1230 (1985).
K. Sula, Z. Zidek, and K. Nouza, Effects of adamantylamide dipeptide (AdDP) on cell mediated immunity in vivo, in: “Immunotherapeutic Prospects of Infectious Diseases,” K. N. Masihi and W. Lange, eds., Springer Verlag, Berlin (1990).
J. Müller, K. Nouza, A. Macakova, K. Sula, and Z. Zidek, Ex vivo and in vivo effects of adamantylamide dipeptide (AdDP) on macrophages and lymphocytes, in: “Immunotherapeutic Prospects of Infectious Diseases,” K. N. Masihi and W. Lange, eds., Springer Verlag, Berlin (1990).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Masihi, K.N., Rohde-Schulz, B., Masek, K., Palache, B. (1992). Antiviral and Adjuvant Activity of Immunomodulator Adamantylamide Dipeptide. In: Friedman, H., Klein, T.W., Yamaguchi, H. (eds) Microbial Infections. Advances in Experimental Medicine and Biology, vol 319. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3434-1_28
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3434-1_28
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6519-8
Online ISBN: 978-1-4615-3434-1
eBook Packages: Springer Book Archive