Stimulation of Host-Defense Mechanism with Synthetic Adjuvants and Recombinant Cytokines Against Viral Infection in Mice

  • Ichiro Azuma
  • Chiaki Ishihara
  • Joji Iida
  • Yung Choon Yoo
  • Kumiko Yoshimatsu
  • Jiro Arikawa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 319)


The efficacy of synthetic immunoadjuvants and recombinant cytokines for the potentiation of host-resistance against virus infection was investigated using mouse models infected with Sendai virus and herpes simplex type 1 virus (HSV). The synthetic MDP derivative, MDP-Lys(L18), and recombinant cytokines, IL-1β, IFN-γ, G-CSF and GM-CSF were shown to be effective for the stimulation of nonspecific protection against Sendai virus infection in mice. Both MDP-Lys(L18) and GM-CSF were effective for the protection against HSV infection in cyclophosphamide (CY)-treated mice. B30-MDP was suggested to be useful as an immunoadjuvant for the potentiation of antigenicity of recombinant or component vaccines.


Intranasal Administration Hemorrhagic Fever With Renal Syndrome Sendai Virus Adjuvant Activity Muramyl Dipeptide 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Ichiro Azuma
    • 1
  • Chiaki Ishihara
    • 1
    • 2
  • Joji Iida
    • 1
  • Yung Choon Yoo
    • 1
  • Kumiko Yoshimatsu
    • 1
  • Jiro Arikawa
    • 1
  1. 1.Institute of Immunological ScienceHokkaido UniversitySapporoJapan
  2. 2.School of Veterinary MedicineRakuno-Gakuen UniversityEbetsuJapan

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