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Selective Alterations in N-Methyl-D-Aspartate Receptor Coupled Responses with Aging: Implications for Therapy

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Treatment of Dementias

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 40))

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Abstract

The search for the underlying neurochemical causes of dementia due to Alzheimer’s disease and aging has continued in earnest over the past few years. Although the cholinergic hypothesis has attracted much attention and experimental effort, another hypothesis is coming to the forefront due in large part to advances in our understanding of the neurochemical basis of learning and memory. This new hypothesis, the glutamatergic hypothesis, does not necessarily exclude the cholinergic hypothesis or others, but may provide an additional perspective for experimental design and the development of potential therapies for cognitive disorders associated with aging or Alzheimer’s disease.

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Authors and Affiliations

  1. Institute for Neuroscience and College of Pharmacy, University of Texas, Austin, Texas, USA

    Rueben A. Gonzales, Laurie M. Brown, Timothy Schallert, Melanie S. Weaver & Khalid M. Shumburo

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  1. Rueben A. Gonzales
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  2. Laurie M. Brown
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  3. Timothy Schallert
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  4. Melanie S. Weaver
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  5. Khalid M. Shumburo
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Editors and Affiliations

  1. University of Florida, Gainesville, Florida, USA

    Edwin M. Meyer , James W. Simpkins  & Fulton T. Crews ,  & 

  2. Taiho Pharmaceutical Company, Tokushima, Japan

    Jyunji Yamamoto

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Gonzales, R.A., Brown, L.M., Schallert, T., Weaver, M.S., Shumburo, K.M. (1992). Selective Alterations in N-Methyl-D-Aspartate Receptor Coupled Responses with Aging: Implications for Therapy. In: Meyer, E.M., Simpkins, J.W., Yamamoto, J., Crews, F.T. (eds) Treatment of Dementias. Advances in Behavioral Biology, vol 40. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3432-7_20

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