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Seizure-Dependent Regulation of BDNF mRNA in the Rat Brain

  • Millicent M. Dugich-Djordjevic
  • Paul A. Lapchak
  • Franz Hefti
Part of the Advances in Behavioral Biology book series (ABBI, volume 40)

Abstract

Brain derived neurotrophic factor (BDNF) is a 13.5 kD polypeptide related to nerve growth factor (NGF), neurotrophin-3 (NT3) and neurotrophin-4 (NT4), (for review see Lapchak et al., this volume), and which has been shown to promote the survival and differentiation of in vitro neuronal populations (Davies et al., 1986; Johnson et al., 1986; Alderson et al., 1990; Hyman et al., 1990; Knusel et al., 1990). Similar to NGF and NT3, BDNF mRNA is expressed in the target regions of the basal forebrain cholinergic system, with highest levels occurring in the hippocampal pyramidal, hilar and granule subregions (Hofer et al., 1990; Phillips et al., 1990; Wetmore et al., 1990; Dugich-Djordjevic et al., 1991a). Moreover, the expression of BDNF mRNA is localized to neuronal cell populations in hippocampal subregions (Wetmore et al., 1990; Dugich-Djordjevic et al., 1991a), and a possible localization to the neuropil in certain brain regions has been suggested (Dugich-Djordjevic et al., 1991b).

Keywords

Nerve Growth Factor Brain Derive Neurotrophic Factor Piriform Cortex Hippocampal Subregion Kainic Acid Administration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ben-Ari, Y. (1985) Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy. Neuroscience. 14, 375–403.PubMedCrossRefGoogle Scholar
  2. Ben-Ari, Y. and A. Represa (1990) Brief seizure episodes induce long-term potentiation and mossy fiber sprouting in the hippocamapus Trends Neurosci., 13, 312–317.Google Scholar
  3. Ben-Ari, Y, E. Tremblay, D. Riche, G. Ghilini, and R. Naquet (1981) Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: Metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy. Neuroscience, 6, 1361– 1391.Google Scholar
  4. Davies, A.M., H. Thoenen, and Y-A. Barde (1986) The response of chick sensory neurons to brain-derived neurotrophic factor. J. Neurosci., 6, 1897–1904.PubMedGoogle Scholar
  5. Davies, A.M., H. Thoenen, and Y-A. Barde (1986) The response of chick sensory neurons to brain-derived neurotrophic factor. J. Neurosci., 6, 1897–1904.PubMedGoogle Scholar
  6. Dugich-Djordjevic, M., G. Tocco, G.M. Pasinetti, P.A. Lapchak, I. Najm, R. Thompson, M. Baudry, and F. Hefti (1991b) BDNF mRNA expression following kainic acid seizure activity in the developing rat (submitted).Google Scholar
  7. Ernfors, P., J. Bengzon, Z. Kokaia, H. Persson, and O. Lindvall (1991). Increased levels of messenger RNAs for neurotrophic factors in the brain during kindled epileptogenesis. Neuron, 7, 165–176.PubMedCrossRefGoogle Scholar
  8. Ernfors, P., J. Bengzon, Z. Kokaia, H. Persson, and O. Lindvall (1991). Increased levels of messenger RNAs for neurotrophic factors in the brain during kindled epileptogenesis. Neuron, 7, 165–176.PubMedCrossRefGoogle Scholar
  9. Hefti, F., T. Denton, B. Knusel, and P.A. Lapchak. Lapchak “Neurotrophic factors: What are they and what are they doing?” in: Neurotrophic Factors. S.E. Loughlin and J.H. Fallon (eds.), Academic Press, 1990.Google Scholar
  10. Hofer, M., S.R. Pagliusi, A. Hohn, J. Leibrock, and Y-A. Barde (1990) Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO Journal, 9, 2459–2464.PubMedGoogle Scholar
  11. Hyman, C., M. Hofer, Y-A. Barde, M. Juhasz, G.D. Yanacopoulos, S. Squinto, and R. M. Lindsey. (1990) BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature, 350, 230–233.CrossRefGoogle Scholar
  12. Johnson, J.E., Y-A. Barde, M. Schwab, and H. Thoenen (1986) Brain-derived neurotrophic factor supports the survival of cultured retinal ganglion cells. J. Neurosci., 6, 3031–3038.PubMedGoogle Scholar
  13. Knusel, B., J.W. Winslow, A. Rosenthal, L.E. Burton, D.P. Seid, Nikolics, and F. Hefti (1991) Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin-3. Proc. Natl. Acad. Sci. U.S.A., 88, 961–965.PubMedGoogle Scholar
  14. Lothman, E.W. and R.C. Collins (1981) Kainic acid induced limbic seizures: Metabolic, behavioral, electroencephalographic and neuropathological correlates. Brain Res., 218, 299–318.PubMedCrossRefGoogle Scholar
  15. Maisonpierre, P.C., B.F. Belluscio, R.F. Alderson, S.J. Wiegand, M.E. Furth, R.M. Lindsay, and G.D. Yancopoulos (1990) NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression. Neuron, 5, 501–509.PubMedCrossRefGoogle Scholar
  16. Nadler, J.V., B.W. Perry, C. Gentry, and C. W. Cotman (1981) Fate of the hippocampal mossy fiber projection after destruction of its postsynaptic targets with intraventricular kainic acid. J. Comp. Neurol., 196, 549–569.PubMedCrossRefGoogle Scholar
  17. Nitecka, L., E. Tremblay, G. Charton, J.P. Bouillot, M.L. Berger, and Y. Ben-Ari (1984) Maturation of kainic acid-brain damage syndrome in the rat II. Histopathological sequelae. Neuroscience, 13, 1073–1094.PubMedCrossRefGoogle Scholar
  18. Phillips, H.S., J.M. Hains, G.R. Laramee, A. Rosenthal, and J.W. Winslow (1990) Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons. Science, 250, 290–294.PubMedCrossRefGoogle Scholar
  19. Petit, T.L., J.C. LeBoutillier, E.J. Markus, and N.W. Milgram (1989) Synaptic structural plasticity following repetitve activation in the rat hippocampus. Exp. Neurol., 105, 72–79.PubMedCrossRefGoogle Scholar
  20. Sloviter, R.S. (1987) Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy. Science, 235, 73–76.PubMedCrossRefGoogle Scholar
  21. Tremblay, E., L. Nitecka, M.L. Berger, and Y. Ben-Ari (1984) Maturation of kainic acidseizure-brain damage syndrome in the rat. I. Clinica, electrographic and metabolic observations. Neuroscience, 13, 1051–1072.PubMedCrossRefGoogle Scholar
  22. Wetmore, C., P. Ernfors, H. Persson, and L. Olson (1990) Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization. Exp. Neurol., 190, 141–152.CrossRefGoogle Scholar
  23. Zafra, F., B. Hengerer, J. Leibrock, H. Thoenen, and D. Lindholm (1990) Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. EMBO J., 9, 3545–3550.PubMedGoogle Scholar
  24. Zimmer, J., and F.-M. S. Haug (1978) Laminar differentiation of the hippocampus, fascia dentata and subiculum in developing rats, observed with the Timm sulphide method. J. Comp. Neurol., 179, 581–618.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Millicent M. Dugich-Djordjevic
    • 1
  • Paul A. Lapchak
    • 1
  • Franz Hefti
    • 1
  1. 1.Andrus Gerontology CenterUniveresity of Southern CaliforniaLos AngelesUSA

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