Distribution Pattern of Capillary and Venular Red Blood Cell Velocity Following Ischemia-Reperfusion in Striated Muscle*
Microvascular red blood cell (RBC) velocity in striated muscle fluctuates with time and varies from capillary to capillary (Ellis et al., 1990). The heterogeneity of microvascular RBC-velocity is known to be enhanced in pathologic conditions, such as ischemia-reperfusion (Tyml and Budreau, 1988; Menger et al., 1988). Previous studies have shown that microvascular ischemia-reperfusion injury is located primarily in nutritive capillaries and postcapillary venules (Menger et al., 1989; Lehr et al., 1991; Granger et al., 1989). The aim of the present study was to analyze the distribution pattern of capillary and venular RBC-velocity following ischemia-reperfusion to striated muscle. Using the hamster dorsal skinfold preparation intravital fluorescence microscopy provides a direct access to the striated muscle microcirculation, allowing repeated observations over a prolonged period of time in the awake animal, including quantitative analysis of different microhemodynamic parameters (Endrich et al., 1980).
KeywordsPermeability Titanium Catheter Ischemia Adenosine
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- Ellis, C.G., Wrigley, S.M., Potter, R.F., and Groom, A.C., 1990, Temporal distributions of red cell supply rate to individual capillaries of resting skeletal muscle, in frog and rat, Int. J. Microcir.: Clin. Exp., 9: 67.Google Scholar
- Lewis, D.H., 1984, The response of the microvasculature in skeletal muscle to hemorrhage, trauma; and ischemia, Prog. Appl. Microcirc, 5: 127.Google Scholar
- Menger, M.D., Hammersen, F., Barker, J., Feifel, G., and Messmer, K., 1989, Ischemia and reperfusion in skeletal muscle: Experiments with tourniquet-ischemia in the awake Syrian golden hamster. Prog. Appl. Microcirc, 13: 93.Google Scholar
- Tyml, K., and Budreau, C.H., 1988, Heterogeneity of microvascular response to ischemia in skeletal muscle, Int. J. Microcirc: Clin. Exp., 7: 205.Google Scholar