Distribution Pattern of Capillary and Venular Red Blood Cell Velocity Following Ischemia-Reperfusion in Striated Muscle*

  • Michael D. Menger
  • Gernot Feifel
  • Konrad Messmer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 317)


Microvascular red blood cell (RBC) velocity in striated muscle fluctuates with time and varies from capillary to capillary (Ellis et al., 1990). The heterogeneity of microvascular RBC-velocity is known to be enhanced in pathologic conditions, such as ischemia-reperfusion (Tyml and Budreau, 1988; Menger et al., 1988). Previous studies have shown that microvascular ischemia-reperfusion injury is located primarily in nutritive capillaries and postcapillary venules (Menger et al., 1989; Lehr et al., 1991; Granger et al., 1989). The aim of the present study was to analyze the distribution pattern of capillary and venular RBC-velocity following ischemia-reperfusion to striated muscle. Using the hamster dorsal skinfold preparation intravital fluorescence microscopy provides a direct access to the striated muscle microcirculation, allowing repeated observations over a prolonged period of time in the awake animal, including quantitative analysis of different microhemodynamic parameters (Endrich et al., 1980).


Syrian Golden Hamster Postcapillary Venule Awake Animal Postischemic Reperfusion Intravital Fluorescence Microscopy 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Michael D. Menger
    • 1
  • Gernot Feifel
    • 2
  • Konrad Messmer
    • 1
  1. 1.Institute for Surgical ResearchUniversity of MunichGermany
  2. 2.Department of General SurgeryUniversity of SaarlandHomburg/ SaarGermany

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