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Cerebral Blood Flow and Brain Mitochondrial Redox State Responses to Various Perturbations in Gerbils

  • A. Mayevsky
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 317)

Abstract

The interrelation between cerebral blood flow and metabolism is an important factor in understanding brain functions under normal and pathological situations. Since few of the situations, such as spreading depression and epilepsy, are transient and are not in steady state it became necessary to monitor the various parameters under observation in real time and in a continuous mode. Until recently CBF monitoring was limited to a single time point per animal using mapping technique or to a 10–15 minutes interval between single measurements. The development of the Laser Doppler flowmeter (LDF) opened up the possibility of monitoring CBF in a real time continuous mode (Stern et al 1977). As shown by a few groups, the CBF monitored by the LDF technique was significantly correlated to the flow measured by other quantitative techniques (Haberl et al 1989; Dirnagl et al 1989). Since CBF is only one of the important parameters to be measured we incorporated a laser Doppler probe into the multiprobe assembly developed by us a few years ago (Friedli et al 1982; Mayevsky 1983). Since all the probes used in the MPA are surface probes we also monitored the CBF from the surface of the brain.

Keywords

Cerebral Blood Flow Cortical Spreading Depression Spreading Depression Mongolian Gerbil Carotid Artery Occlusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • A. Mayevsky
    • 1
  1. 1.Department of Life SciencesBar-llan UniversityRamat-GanIsrael

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