Cerebral Blood Flow and Brain Mitochondrial Redox State Responses to Various Perturbations in Gerbils

  • A. Mayevsky
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 317)


The interrelation between cerebral blood flow and metabolism is an important factor in understanding brain functions under normal and pathological situations. Since few of the situations, such as spreading depression and epilepsy, are transient and are not in steady state it became necessary to monitor the various parameters under observation in real time and in a continuous mode. Until recently CBF monitoring was limited to a single time point per animal using mapping technique or to a 10–15 minutes interval between single measurements. The development of the Laser Doppler flowmeter (LDF) opened up the possibility of monitoring CBF in a real time continuous mode (Stern et al 1977). As shown by a few groups, the CBF monitored by the LDF technique was significantly correlated to the flow measured by other quantitative techniques (Haberl et al 1989; Dirnagl et al 1989). Since CBF is only one of the important parameters to be measured we incorporated a laser Doppler probe into the multiprobe assembly developed by us a few years ago (Friedli et al 1982; Mayevsky 1983). Since all the probes used in the MPA are surface probes we also monitored the CBF from the surface of the brain.


Cerebral Blood Flow Cortical Spreading Depression Spreading Depression Mongolian Gerbil Carotid Artery Occlusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Borgos, J.A., TSF’s LDV blood flowmeter in: Laser Doppler blood flowmetry. Edited by Shepherd, A.P., Oberg, P.A. Kluwer Academic Publishers pp. 73–91 (1988).Google Scholar
  2. Bures, J., and Buresova, O., 1984, Susceptibility to spreading depression and anoxia: regional differences and drug control. In: Mechanisms of cerebral Hypoxia and Stroke, ed. G. Somjen Plenum Press N.Y. pp. 253–267.Google Scholar
  3. Chance, B., Cohon, P., Jöbsis, F.F., and Schoener, B., 1962, Intracellular oxidation-reduction states in vivo. Science 137: 499–508.PubMedCrossRefGoogle Scholar
  4. Chance, B., Oshino, N., Sugano, T., and Mayevsky, A., 1973, Basic principles of tissue oxygen determination from mitochondrial signals. Internat. Symposium on Oxygen Transport to tissue. In: Adv. Exp. Med. Biol. Vo. 37A, Plenum Pub. Corp., N.Y. 239–244.Google Scholar
  5. Dirnagl, U., Kaplan, B., Jacewicz, M., and Pulsinelli, W., 1989, Continuous measurement of cerebral cortical blood flow by Laser Doppler Flowmetery with a rat stroke model. J. CBF and Metabol. 9: 589–596.Google Scholar
  6. Erecinska M., and Silver, I.A., 1989, ATP and brain function. J. CBF and Metabol. 9: 2–19.Google Scholar
  7. Friedli, C.M., Sclarsky, D.L., and Mayevsky, A., 1982, A new multiprobe assembly for surface monitoring of ionic, metabolic and electrical activities in the awake brain. Am. J. Physiol. 243: R642 - R469.Google Scholar
  8. Haberl, R.L., Heizer, M.L., Marmarou, A., Ellis, E.F., 1989, Laser doppler assessment of brain microcirculation: Effect of systemic alterations. Am. J. Physiol. 256: H1247–1254.PubMedGoogle Scholar
  9. Lauritzen, M., 1987, Cerebral blood flow in migraine and cortical spreading depression. Acta Neurol. Scand. 76 (Suppl 113): 1–14.CrossRefGoogle Scholar
  10. Leao, A.A.P., 1944a, Spreading depression of activity in cerebral cortex. J. Neurophysiol. 7: 359–390.Google Scholar
  11. Leao, A.A.P., 1944b, Pial circulation and spreading depression of activity in the cerebral cortex. J. Neurophysiol. 7: 391–396.Google Scholar
  12. Mayevsky, A., 1983, Multiparameter monitoring of the awake brain under hyperbaric oxygenation J. Appl. Physiol. 54: 740–748.PubMedGoogle Scholar
  13. Mayevsky, A., 1984, Brain NADH redox state monitored in vivo by fiber optic surface fluorometry. Brain Res. Rev. 7: 49–68.CrossRefGoogle Scholar
  14. Mayevsky, A., 1990, Level of ischemia and brain functions in the Mongolian gerbil in vivo. Brain Res., 524: 1–9.Google Scholar
  15. Mayevsky, A., and Breuer, Z., The Mongolian geruil as a model for cerebral ischemia, In: “Cerebral Ischemia and Cerebral Resuscitation”, Schurr, A., and Rigor, B.M. Eds., CRC Press pp. 27–46 (1990).Google Scholar
  16. Mayevsky, A., and Weiss, H.R., 1991 Cerebral blood flow and oxygen consumption in cortical spreading depression. J. CBF and Metabol. (In press).Google Scholar
  17. Mayevsky, A., Flamm, E.S., Pennie, W., and Chance, B., 1991 A fiber optic based multiprobe system for intraoperative monitoring of brain functions. SPIE Proc. Vol 1431 pp 303–313.CrossRefGoogle Scholar
  18. Mayevsky, A., Zarchin, N., and Friedli, C.M., 1982, Factors affecting the oxygen balance in the awake cerebral cortex exposed to spreading depression. Brain Res. 236: 93–105.PubMedCrossRefGoogle Scholar
  19. Stern, M.D., Lappe, D.L., Bowen, P.D., Chimosky, J.E., Holoway, G.A., Keiser, H.R., and Bowen, P.D., 1977, Continuous measurement of tissue blood flow by Laser-Doppler spectroscopy. Am. J. Physiol. 256: H1247–1254.Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • A. Mayevsky
    • 1
  1. 1.Department of Life SciencesBar-llan UniversityRamat-GanIsrael

Personalised recommendations