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Active and Basal Whole Brain Blood Flow, Oxygen and Glucose Metabolism in Monkeys

  • Edwin M. Nemoto
  • Liping Yao
  • Howard Yonas
  • Joseph Darby
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 317)

Abstract

By definition, active cerebral metabolic rate for oxygen (ACMRO2) is the oxygen consumption associated with the generation of spontaneous electrical activity.1 The balance, or basal CMRO2, is presumably, the oxygen consumed to maintain neuronal viability through ion pumping and reparative and synthetic metabolic pathways.2 This concept evolved out of interest in the mechanism of action of anesthetics and the hypothesis that the effect of anesthetics on cerebral metabolism is secondary to a direct effect on cerebral function.3

Keywords

Cerebral Blood Flow Mean Arterial Blood Pressure Cerebral Metabolic Rate Brain Blood Flow Basal Compartment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    J. D. Michenfelder, The interdependency of cerebral functional and metabolic effects following massive doses of thiopental in the dog, Anesthesiology 41: 231 (1974).PubMedCrossRefGoogle Scholar
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    J. Astrup, P. M. Sorensen, H. R. Sorensen, Oxygen and glucose consumption related to Na+-K+ transport in canine brain, Stroke 12: 726 (1981).PubMedCrossRefGoogle Scholar
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    S. S. Kety, Discussion. Pharmacol Rev 17: 230 (1965).Google Scholar
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    J. D. Michenfelder, R. A. Theye, In vivo toxic effects of halothane on canine cerebral metabolic pathways, Am. J. Physiol. 229:1050 (1975).PubMedGoogle Scholar
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    E. M. Nemoto, J. A. Melick, P. M. Winter, Active and basal cerebrometabolic rate for oxygen (CMRO2) after complete global brain ischemia in rats, in: Oxygen transport to tissue X.M. Mochizuki, C. R. Honig, T. Koyama, T. K. Goldstick, D.F. Bruley, eds., Plenum Publishing Corp., New York, 1988.Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Edwin M. Nemoto
    • 1
  • Liping Yao
    • 1
  • Howard Yonas
    • 1
  • Joseph Darby
    • 1
  1. 1.Departments of Anesthesiology/CCM and Neurological SurgeryUniversity of PittsburghPittsburghUSA

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