Elaboration of Fluorocarbon Emulsions with Improved Oxygen-Carrying Capabilities

  • Jean G. Riess
  • Marie-Pierre Krafft
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 317)


The notion one has of the fluorocarbon-based approach to injectable oxygen carriers is still too often associated with the earlier Fluosol®-type emulsions. The fact that Fluosol has been approved, although only for a limited number of applications, as an adjunct during percutaneous transluminal coronary angioplasty (PTCA), means that the intravascular administration of fluorocarbon emulsions is considered safe by the FDA, and that oxygen transport capacity has been recognized for this preparation, in spite of its low concentration and other limitations.1 Very similar 20% w/v concentrated emulsions have been developed in the Soviet Union and in China under the names Ftorosan and Emulsions n° II, respectively.


Oxygen Carrier Concentrate Emulsion Blood Substitute Oxygen Transport Capacity Perfluorocarbon Emulsion 
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  1. 1.
    J. G. Riess, Fluorocarbon-based blood substitutes, Artif. Org. 14: 255 (1991).Google Scholar
  2. 2.
    J. G. Riess, Hemocompatible fluorocarbon emulsions, in: “Blood Compatible Materials and Devices” C. P. Sharma, M. Szycher, eds., Technomics Publ. C°, Lancaster, Pa USA (1990), Chap. 14, 237.Google Scholar
  3. 3.
    K. C. Lowe, Synthetic oxygen transport fluids based on perfluorochemicals: Applications in medicine and biology, Vox Sang, 60: 129 (1991).CrossRefGoogle Scholar
  4. 4.
    J. G. Riess, Fluorocarbon-based in vivo oxygen transport and delivery systems, Vox Sang. 60, X XX.Google Scholar
  5. 5.
    J. G. Riess, Reassessment of criteria for the selection of perfluorochemicals for second-generation blood substitutes: Analysis of structure/property relationships, Artif. Org. 8: 44 (1984).CrossRefGoogle Scholar
  6. 6.
    R., Mitten, A. R. Burgan, A. Hamblin, G. Yee, D. C. Long, D. M. Long and R. F. Mattrey, Dose related biodistribution & elimination of 100% PFOB emulsion, in: “Blood Substitutes”, T. M. S. Chang, R. P. Geyer, eds, Marcel Dekker, New York (1989), p. 671.Google Scholar
  7. 7.
    J. G. Riess, C. Arlen, J. Greiner, M. Le Blanc, A. Manfredi, S. Pace and C. Varescon, Design, synthesis and evaluation of fluorocarbons and surfactants for in vivo applications. New perfluoroalkylated polyhydroxylated surfactants, in: “Blood Substitutes”, T. M. S. Chang, R. P. Geyer, eds, Marcel Dekker, New York (1989), p. 421.Google Scholar
  8. 8.
    D. Long, D. M. Long, J. G. Riess, R. Follana, A. Burgan and R. Mattrey, Preparation and application of highly concentrated perfluoroctylbromide fluorocarbon emulsions, in: “Blood Substitutes”, T. M. S. Chang, R. P. Geyer, eds, Marcel Dekker, New York (1989), p. 441.Google Scholar
  9. 9.
    J G. Riess, J. L. Dalfors, G. K. Hanna, D. H. Klein, M-P. Krafft, T. J. Pelura and E. G. Schutt, Development of highly fluid, concentrated and stable fluorocarbon emulsions for diagnosis and therapy, Proceed. Intl. Svmp. Blood Substitutes,Google Scholar
  10. 10.
    R. Follana, D. Klein, M.-P. Krafft, D. M. Long, C. D. Long, J. G. Riess and A. Valla, Prolonged shelf life and biocompatibility of a concentrated injectable fluorocarbon emulsion, Proceed. Intl. Svmp. Blood Substitutes., Montreal, 1991.Google Scholar
  11. 11.
    M.-P. Krafft, J.-P. Rolland and J. G. Riess, Detrimental effect of excess lecithin on the stability of fluorocarbon/lecithin emulsions, J. Phys. Chem. 95:xxxx (1991).CrossRefGoogle Scholar
  12. 12J.
    G. Riess and M. Postel, Stability and stabilization of fluorocarbon emulsions, Proceed. Intl. Svmp. Blood Substitutes. Montreal, 1991.Google Scholar
  13. 13.
    M.-P. Krafft, J. P. Rolland and J. G. Riess, unpublished results.Google Scholar
  14. 14.
    M.-P. Krafft, F. Giulieri and J. G. Riess, unpublished results.Google Scholar
  15. 15.
    J. L. Dalfors, Terminal sterilization of perfluorocarbon emulsions: Difficulties and possible solutions, Proceed. Intl. Svmp. Blood Substitutes, Montreal 1991.Google Scholar
  16. 16.
    G. K. Hanna, M. C. Ojeda and T. A. Sklenar, Application of computer-based experimental design to optimization of processing conditions for perfluorocarbon emulsion, Proceed. Intl. Symp. Blood Substitutes, Montreal, 1991.Google Scholar
  17. 17.
    R. Naito and K. Yokoyama, Perfluorochemical blood substitutes, FC-43 emulsion Fluosol-DA, 20% and 35%, Technical Information Ser. n°s 5 and 7 (The Green Cross Corp., Osaka, Japan ( 1978, 1981 ).Google Scholar
  18. 18.
    F. F. Beloyartsev, E. I. Mayevsky and B. I. Islamov, Ftorosan-oxygen carrying perfluorochemical plasma substitute, Acad. Sci. USSR, Pushchino (1983).Google Scholar
  19. 19.
    H.-S. Chen, Z.-H. Yang et al, Perfluorocarbon as blood substitute in clinical applications and in war casualties, in: “Blood Substitutes”. T. M. S. Chang, R. P. Geyer, eds, Marcel Dekker, New York (1989), p. 403.Google Scholar
  20. 20.
    H. Ohyanagi, Y. Saitoh, T. Mitsuno, M. Watanabe, K. Yamanouchi and K. Yokoyama, A new perfluorochemical emulsion: An overview, Intl. J. Artif. Org. 14: 199 (1990).Google Scholar
  21. 21.
    R. E. Moore, Physical properties of a new synthetic oxygen carrier, Biomat., Art. Cells. Art. Org. 16: 443 (1988).Google Scholar
  22. 22.
    Therox, Fluorochemical Oxygen Carriers, DuPont, presentation brochureGoogle Scholar
  23. 23.
    R. J. Kaufman, Fluorocarbon emulsions as blood substitutes, Workshop on Emulsions. Bergen, Norway, June 1991.Google Scholar
  24. 24.
    J. G. Riess, Fluorocarbon-based oxygen carriers: New orientations. Artif. Org. 14:xxx (1991).Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Jean G. Riess
    • 1
  • Marie-Pierre Krafft
    • 1
  1. 1.Laboratoire de Chimie Moléculaire, Associé au CNRSUniversité de Nice-Sophia Antipolis, Parc ValroseNiceFrance

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