Behavioral and Morpho-Functional Correlates of Brain Aging: A Preclinical Study with Phosphatidylserine

  • Maria Grazia Nunzi
  • Diego Guidolin
  • Lucia Petrelli
  • Patrizia Polato
  • Adriano Zanotti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 318)


In the aging brain, changes in membrane lipid composition or content have been related to reduction of membrane fluidity, loss of enzymatic activities, and decreased efficiency of signal transduction and transport mechanisms (Schroeder, 1984). This has led to the assumption that administration of endogenously occurring phospholipids may preserve both structural and functional integrity of central nervous system membranes and prevent, or restore, neuronal deficits that occur with aging or age-related neurodegenerative disorders. Furthermore, exogenous phospholipids may participate in phospholipid metabolism, yielding biologically active intermediates in response to physiopathological phenomena (Toffano and Bruni, 1980; Bruni, 1988).


Morris Water Maze Cholinergic Neuron Basal Forebrain Escape Latency Neurobiol Aging 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Maria Grazia Nunzi
    • 1
  • Diego Guidolin
  • Lucia Petrelli
    • 1
  • Patrizia Polato
    • 1
  • Adriano Zanotti
    • 1
  1. 1.Fidia Research LaboratoriesAbano TermeItaly

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