Impact of Dietary Fatty Acid Balance on Membrane Structure and Function of Neural Tissues

  • M. T. Clandinin
  • M. Suh
  • K. Hargreaves
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 318)

Abstract

Neural tissue has generally been viewed as resistant to structural changes induced by exogenous factors. Research has shown that the brain responds to changes in diet by altering neurotransmitter synthesis, and by shifting neuroendocrine controls over a variety of physiological events. Animal model research also indicates that fatty acid constituents and synthesis of brain structural lipid in membranes undergoing turnover can be altered by changing the composition of dietary fat. In growing animals, the balance between dietary ω6 and ω3 fatty acids influences brain phospholipid fatty acid composition, phosphatidylethanolamine methyltransferase activity, and rate of phosphatidylcholine biosynthesis via the CDP-choline pathway. It is concluded that biosynthetic control mechanisms regulating synthesis of brain structural lipid, in particular phosphatidylcholine, respond to exogenous factors and represent a normal physiological response by the brain. This response may provide a mechanism for therapeutic treatment of disorders involving degeneration of brain structural lipid.

Keywords

Cholesterol Retina Choline Acetylcholine Triglyceride 

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References

  1. Ailing C, Bruce A, Karlsson I, Svennerholm L (1972) The effect of different dietary levels of essential fatty acids on growth of the rat. Nutr Metab 16: 38.Google Scholar
  2. Aloia RC and Raison JK (1989) Membrane function in mammalian hibernation. Biochim Biophys Acta 988: 123.PubMedCrossRefGoogle Scholar
  3. Aveldaño MI (1988) Phospholipid species containing long and very long polyenoic fatty acids remain with rhodopsin after hexane extraction of photoreceptor membranes. Biochemistry 27: 1229.PubMedCrossRefGoogle Scholar
  4. Aveldaño MI and Bazan NG (1983) Molecular species of phosphatidylcholine,-ethanolamine,-serine, and-inositol in microsomal and photoreceptor membranes of bovine retina. J Lipid Res 24: 620.PubMedGoogle Scholar
  5. Aveldaño MI, Pasquare deGarcia SJ, Bazan NG (1983) Biosynthesis of molecular species of inositol, choline, serine and ethanolamine glycerophospholipids in the bovine retina. J Lipid Res 24: 628.PubMedGoogle Scholar
  6. Bazan NG, Reddy TS, Bazan HEP, Birkle DL (1986) Metabolism of arachidonic and docosahexaenoic acids in the retina. Prog Lipid Res 25: 595.PubMedCrossRefGoogle Scholar
  7. Bazan NG, Reddy TS, Redmond TM, Wiggert B, Chader GJ (1985) Endogenous fatty acids are covalently and noncovalently bound to interphotoreceptor retinoid-binding protein in the monkey retina. J Biol Chem 260: 13677.PubMedGoogle Scholar
  8. Birkle DL and Bazan NG (1989) Light exposure stimulates arachidonic acid metabolism in intact rat retina and isolated rod outer segments. Neurochem Res 14: 185.Google Scholar
  9. Blustajn JK and Wurtman RJ (1984) Alzheimer’s disease: Advances in basic research and therapies (Wurtman RJ, Corkin SH, Growdon JH, eds) pp 183–198. Center for Brain Sciences and Metabolism Charitable Trust.Google Scholar
  10. Bremer J and Greenberg DM (1961) Methyl transferring enzyme system of microsomes in the biosynthesis of lecithin (phosphatidylcholine). Biochim Biophys Acta 46: 205.CrossRefGoogle Scholar
  11. Capaldi RA, ed (1977) Membrane proteins and their interaction with lipids. Vol 1, New York: Marcel Dekker.Google Scholar
  12. Clandinin MT, Cheema S, Field CJ, Garg ML, Venkatraman J, Clandinin TR (1991) Dietary fat: Exogenous determination of membrane structure and cell function. FASEB J 5: 2761.PubMedGoogle Scholar
  13. Clandinin MT, Field CJ, Hargreaves K, Morson L, Zsigmond E (1985) Role of diet fat in subcellular structure and function. Can J Physiol Pharmacol 63: 546.PubMedCrossRefGoogle Scholar
  14. Cohen EL and Wurtman RJ (1976) Brain acetylcholine: Control by dietary choline. Science 191: 561.PubMedCrossRefGoogle Scholar
  15. Foot M, Cruz T, Clandinin MT (1983) Effect of dietary lipids on synaptosomal acetylcholinesterase activity. Biochem J 211: 507.PubMedGoogle Scholar
  16. Foot M, Cruz TF, Clandinin MT (1982) Influence of dietary fat on the lipid composition of rat brain synaptosomal and microsomal membranes. Biochem J 208: 631.PubMedGoogle Scholar
  17. Garg ML, Sebokova E, Thomson ABR, Clandinin MT (1988) Delta6-desaturase activity in liver microsomes of rats fed diets enriched with cholesterol and/or omega-3 fatty acids. Biochem J 249: 351.PubMedGoogle Scholar
  18. Gould RM and Dawson RMC (1976) Incorporation of newly formed lecithin into peripheral nerve myelin. J Cell Biol 68: 480.PubMedCrossRefGoogle Scholar
  19. Hannun YA and Bell RM (1989) Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science 243: 500.PubMedCrossRefGoogle Scholar
  20. Hargreaves K and Clandinin MT (1987a) Phosphocholinetransferase activity in plasma membrane: Effect of diet. Biochem Biophys Res Commun 145: 309.PubMedCrossRefGoogle Scholar
  21. Hargreaves K and Clandinin MT (1987b) Phosphatidylethanolamine methyltrans-ferase: Evidence for influence of diet fat on selectivity of substrate for methylation in rat brain synaptic plasma membranes. Biochim Biophys Acta 918: 97.PubMedCrossRefGoogle Scholar
  22. Hargreaves KM and Clandinin MT (1989) Coordinate control of CDP-choline and phosphatidylethanolamine methyltransferase pathways for phosphatidylcholine biosynthesis occurs in response to change in diet fat. Biochim Biophys Acta 1001: 262.PubMedCrossRefGoogle Scholar
  23. Hargreaves K and Clandinin MT (1990) Dietary lipids in relation to postnatal development of the brain. Upsala J Med Sci Suppl 48: 79.Google Scholar
  24. Hoffman DR and Cornatzer WE (1981) Microsomal phosphatidylethanolamine methyltransferase: Some physical and kinetic properties. Lipids 16: 533.PubMedCrossRefGoogle Scholar
  25. Hoffman DR, Haning JA, Cornatzer WE (1981) Microsomal phosphatidylethanolamine methyltransferase: Inhibition by S-adenosylhomocysteine. Lipids 16: 561.PubMedCrossRefGoogle Scholar
  26. Jope RS and Jenden DJ (1979) Choline and phospholipid metabolism and the synthesis of acetylcholine in rat brain. J Neurosci Res 4: 69.PubMedCrossRefGoogle Scholar
  27. Jungalwala FB and Dawson RMC (1971) The turnover of myelin phospholipids in the adult and developing rat brain. Biochem J 123: 683.PubMedGoogle Scholar
  28. Karlsson I (1975) Effects of different dietary levels of essential fatty acids on the fatty acid composition of ethanolamine phosphoglycerides in myelin and synaptosomal plasma membranes. J Neurochem 25: 101.PubMedCrossRefGoogle Scholar
  29. Kikkawa U, Kishimoto A, Nishizuka Y (1989) Theprotein kinase C family: Heterogeneity and its implications. Annu Rev Biochem 58: 31.PubMedCrossRefGoogle Scholar
  30. Le Kim D, Betzing H, Stoffel W (1973) Studies in vitroand in vivoon methylation of phosphatidyl-N-N-dimethylethanolamine to phosphatidylcholine in rat liver. Hoppe Seylers Z Physiol Chem 354: 437.CrossRefGoogle Scholar
  31. Lee RE (1985) Membrane engineering to rejuvenate the aging brain. Can Med Assoc J 132: 325.PubMedGoogle Scholar
  32. Marinetti GV and Cattieu K (1982) Tightly (covalently) bound fatty acids in cell membrane proteins. Biochim Biophys Acta 685: 109.PubMedCrossRefGoogle Scholar
  33. McMurchie EJ (1988) Physiological regulation of membrane fluidity. In: Advances in membrane fluidity (Aloia RC, Curtain CC, Gordon LM, eds) Vol 3, pp 189–237. New York: Alan R. Liss.Google Scholar
  34. Mogelson S and Sobel BE (1981) Ethanolamine plasmalogen methylation by rabbit myocardial membranes. Biochim Biophys Acta 666: 205.PubMedCrossRefGoogle Scholar
  35. Mozzi R, Siepi D, Adreoli V, Porcellati G (1982) Biochemistry of SAM and related compounds (Usdin E, Borchardt RT, Creveling CR, eds) pp 129–138. New York: MacMillan Press.Google Scholar
  36. Reddy TS and Bazan NG (1985) Synthesis of docosahexaenoyl-, arachidonoyl-and palmitoyl-coenzyme A in ocular tissues. Exp Eye Res 41: 87.PubMedCrossRefGoogle Scholar
  37. Reddy TS, Birkle DL, Packer AJ, Dobard P, Bazan NG (1986) Fatty acid composition and arachidonic acid metabolism in vitreous lipids from canine and human eyes. Curr Eye Res 5: 441.PubMedCrossRefGoogle Scholar
  38. Salerno DM and Beeler DA (1973) The biosynthesis of phospholipids and their precursors in rat liver involving de novomethylation and base-exchange pathways, in vivo.. Biochim Biophys Acta 326: 325.PubMedCrossRefGoogle Scholar
  39. Scott BL, Racz E, Lolley RN, Bazan NG (1988) Developing rod photoreceptors from normal and mutant rdmouse retinas: Altered fatty acid composition early in development of the mutant. J Neurosci Res 20: 202.PubMedCrossRefGoogle Scholar
  40. Scott BL, Reddy TS, Bazan NG (1987) Docosahexaenoate metabolism and fatty acid composition in developing retinas of normal and rdmutant mice. Exp Eye Res 44: 101.PubMedCrossRefGoogle Scholar
  41. Singer SJ and Nicolson GL (1972) The fluid mosaic model of the structure of cell membranes. Science 175: 720.PubMedCrossRefGoogle Scholar
  42. Spector AA and Yorek MA (1985) Membrane lipid composition and cellular function. J Lipid Res 26: 1015.PubMedGoogle Scholar
  43. Strittmatter WJ, Hirata F, Axelrod J (1979) Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes. Science 204: 1205.PubMedCrossRefGoogle Scholar
  44. Stubbs CD and Smith AD (1984) The modification of mammalian membrane fluidity and function. Biochim Biophys Acta 779: 89.PubMedCrossRefGoogle Scholar
  45. Tanford C (1978) Hydrophobic effect and organization of living matter. Science 200: 1012.PubMedCrossRefGoogle Scholar
  46. Trewhella MA and Collins FD (1973) Pathways of phosphatidylcholine biosynthesis in rat liver. Biochim Biophys Acta 296: 51.PubMedCrossRefGoogle Scholar
  47. Vance DE and Choy PC (1979) How is phosphatidylcholine biosynthesis regulated? Trends Biochem Sci 4: 145.CrossRefGoogle Scholar
  48. Wurtman RJ, Hefti F, Melamed E (1980) Precursor control of neurotransmitter synthesis. Pharmacol Rev 32: 315.PubMedGoogle Scholar
  49. Yeagle PL (1989) Lipid regulation of cell membrane structure. FASEB J 3: 1833.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • M. T. Clandinin
    • 1
  • M. Suh
    • 1
  • K. Hargreaves
    • 2
  1. 1.Nutrition and Metabolism Research Group, Department of Foods & Nutrition and Department of MedicineUniversity of AlbertaEdmontonCanada
  2. 2.Neurological Research Unit, Department of SurgeryQueen’s UniversityKingstonCanada

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