Impact of Dietary Fatty Acid Balance on Membrane Structure and Function of Neural Tissues

  • M. T. Clandinin
  • M. Suh
  • K. Hargreaves
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 318)


Neural tissue has generally been viewed as resistant to structural changes induced by exogenous factors. Research has shown that the brain responds to changes in diet by altering neurotransmitter synthesis, and by shifting neuroendocrine controls over a variety of physiological events. Animal model research also indicates that fatty acid constituents and synthesis of brain structural lipid in membranes undergoing turnover can be altered by changing the composition of dietary fat. In growing animals, the balance between dietary ω6 and ω3 fatty acids influences brain phospholipid fatty acid composition, phosphatidylethanolamine methyltransferase activity, and rate of phosphatidylcholine biosynthesis via the CDP-choline pathway. It is concluded that biosynthetic control mechanisms regulating synthesis of brain structural lipid, in particular phosphatidylcholine, respond to exogenous factors and represent a normal physiological response by the brain. This response may provide a mechanism for therapeutic treatment of disorders involving degeneration of brain structural lipid.


Microsomal Membrane Ethanolamine Phosphatidyl Synaptic Plasma Membrane Phospholipid Fatty Acid Composition Phospholipid Species 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • M. T. Clandinin
    • 1
  • M. Suh
    • 1
  • K. Hargreaves
    • 2
  1. 1.Nutrition and Metabolism Research Group, Department of Foods & Nutrition and Department of MedicineUniversity of AlbertaEdmontonCanada
  2. 2.Neurological Research Unit, Department of SurgeryQueen’s UniversityKingstonCanada

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