Impact of Dietary Fatty Acid Balance on Membrane Structure and Function of Neural Tissues
Neural tissue has generally been viewed as resistant to structural changes induced by exogenous factors. Research has shown that the brain responds to changes in diet by altering neurotransmitter synthesis, and by shifting neuroendocrine controls over a variety of physiological events. Animal model research also indicates that fatty acid constituents and synthesis of brain structural lipid in membranes undergoing turnover can be altered by changing the composition of dietary fat. In growing animals, the balance between dietary ω6 and ω3 fatty acids influences brain phospholipid fatty acid composition, phosphatidylethanolamine methyltransferase activity, and rate of phosphatidylcholine biosynthesis via the CDP-choline pathway. It is concluded that biosynthetic control mechanisms regulating synthesis of brain structural lipid, in particular phosphatidylcholine, respond to exogenous factors and represent a normal physiological response by the brain. This response may provide a mechanism for therapeutic treatment of disorders involving degeneration of brain structural lipid.
KeywordsCholesterol Retina Choline Acetylcholine Triglyceride
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- Ailing C, Bruce A, Karlsson I, Svennerholm L (1972) The effect of different dietary levels of essential fatty acids on growth of the rat. Nutr Metab 16: 38.Google Scholar
- Birkle DL and Bazan NG (1989) Light exposure stimulates arachidonic acid metabolism in intact rat retina and isolated rod outer segments. Neurochem Res 14: 185.Google Scholar
- Blustajn JK and Wurtman RJ (1984) Alzheimer’s disease: Advances in basic research and therapies (Wurtman RJ, Corkin SH, Growdon JH, eds) pp 183–198. Center for Brain Sciences and Metabolism Charitable Trust.Google Scholar
- Capaldi RA, ed (1977) Membrane proteins and their interaction with lipids. Vol 1, New York: Marcel Dekker.Google Scholar
- Hargreaves K and Clandinin MT (1990) Dietary lipids in relation to postnatal development of the brain. Upsala J Med Sci Suppl 48: 79.Google Scholar
- McMurchie EJ (1988) Physiological regulation of membrane fluidity. In: Advances in membrane fluidity (Aloia RC, Curtain CC, Gordon LM, eds) Vol 3, pp 189–237. New York: Alan R. Liss.Google Scholar
- Mozzi R, Siepi D, Adreoli V, Porcellati G (1982) Biochemistry of SAM and related compounds (Usdin E, Borchardt RT, Creveling CR, eds) pp 129–138. New York: MacMillan Press.Google Scholar