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Neural Implants and Recovery of Function: Human Work

  • Edward Hitchcock
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 325)

Abstract

Organ transplantation is an accepted treatment for renal, hepatic and cardiorespiratory diseases and the principles of harvesting and transplantation technique, together with the maintenance of organ function are well established. The ethical aspects of harvesting have been widely debated52,61 and, in most countries, appropriate regulations have been formulated which support and, indeed, may encourage organ donation. As regards neural transplantation, however, these principles are yet to be agreed and the clinical value established. Consequently, the management of patients with neural degenerative disease, who potentially have much to gain, is uncertain and, the ethical issues are still hotly debated.23,43,47,52,55,61

Keywords

Caudate Nucleus Ventral Mesencephalon Neural Transplantation Stereotactic Technique Open Craniotomy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Allen, G.S., Burns, R.C., Tulipan, N.B., and Parker, R.A, 1988, Adrenal medullary transplantation to the caudate nucleus in Parkinson’s Disease, Arch. Neurol., 46, 487–491.Google Scholar
  2. 2.
    Anden, N.E., Dahlstrom, A., Fuxe, K., and Larsson, K., 1966, Functional role of the nigroneostriatal dopamine neurones, Acta. Pharmacol. Toxicol., 24, 263–274.Google Scholar
  3. 3.
    Backlund, E.O., Granberg, P.O., Hamberger, B., Gedvall, G. Seigar, A., and Olsen, L., 1985, Transplantation of adrenal mdedullary tissue to striatum in Parkinsonism. First clinical trials, J. Neurosurg., 62, 169–173.Google Scholar
  4. 4.
    Bankiewicz, K.S., Jacobowitz, D.M., Plunkett, R.J. Oldfield, E.H., and Kopen, I.J., 1987, Injury induced sprouting into the caudate nucleus, after solid tissue implantation in MPTP-induced Parkinsonism monkeys, Soc. of Neurosc. Abs., 46, 16.Google Scholar
  5. 5.
    Bankiewicz, K.S., Plunkett, R.J., Mefford, I. Kopin, I.J., and Oldfield, E.G., 1990, Behavioural recovery from MPTP-induced Parkinsonism in monkeys after intracerebral tissue implants is not related to CSF concentrations of dopamine metabolites, Prog. in Brain Research, 82, 561–671, Elsevier, Amsterdam.Google Scholar
  6. 6.
    Barker, R.A, Cahn, A.P., 1988, Parkinson’s Disease: an autoimmune process, Int. J Neurol., 43, 1–7.Google Scholar
  7. 7.
    Björklund, A., Dunnett, S.B., Stenevi, U., Lewis, M.E., and Iverson, S.D., 1980, Reinnervation of the denervated striatum by substantia nigra transplants: functional consequences as revealed by pharmacological and sensorimotor testing, Brain Res., 199, 307–333.Google Scholar
  8. 8.
    Björklund, A., Kromer, L.F., and Stenevi, U., 1979, Cholinergic reinnervation of the rat hippocampus by septal implants is stimulated by perforant path lesion, Brain Res., 173, 57–64.Google Scholar
  9. 9.
    Björklund, A., and Stenevi, U., 1979, Regeneration of monoaminergic and cholinergic neurones in the mammalian central nervous system, Physiol. Rev., 59, 62–100.Google Scholar
  10. 10.
    Björklund, A., Stenevi, U., Dunnett, S.B., and Gage, F.H., 1982, Cross species neural grafting in a rat model of Parkinson’s Disease, Nature, 298, 652–654.Google Scholar
  11. 11.
    Brundin, P. Nilsson, O.G., Strecker, R.E., Lindvall, O. Astedt, B., and Björklund, A., 1986, Behavioural effects of human foetal dopamine neurons grafted in a rat model of Parkinson’s Disease, Exp. Brain Res., 65, 235–240.Google Scholar
  12. 12.
    Canter, C.J., De La Torrer, D., Mier, M., 1961, A method for evaluating disability in patients with Parkinson’s Disease, J. Nero. Ment. Dis., 122, 143–147.Google Scholar
  13. 13.
    Collier, T.J., Gash, D.M., and Sladek, J.R, 1988, Transplantation of norepinephrine neurons into aged rats improves performance of a learned task, Brain Res., 448, 77–87.Google Scholar
  14. 14.
    Das, G.D. 1974, Transplantation of embryonic neural tissue in the mammalian brain. Growth and differentiation of neuroblasts from various regions of the embryonic brain in the cerebellum of neonate rats, J. of Life Sci., 93–124.Google Scholar
  15. 15.
    Das, G.D., and Hallas, H.B., 1978, Transplantation of brain tissue in the brain of adult rat, Experimentia, 34, 1304–1306.Google Scholar
  16. 16.
    Deckel, A.W., Robinson, R.G., Coyle, I.T., and Sanberg, P.R., 1983, Reversal of long term locomotor abnormalities in the Kainic Acid model of Huntington’s Disease by day 18 foetal striatal implants, European J. Pharmacol., 93, 287–288.Google Scholar
  17. 17.
    Del Conte, G., 1907, Empflanzungen von embryonalem Gewebe ins Gehurn, Beatr Path Anat. Allg. Pathol., 42, 193–203.Google Scholar
  18. 18.
    Detta, A., Grabham, P., and Hitchcock, E.R., 1992, Phenotypic plasticity of mature human foetal mesencephalic dopaminergic neurones, Restorative NeuroL and NeuroSci., (in press).Google Scholar
  19. 19.
    Detta, A., Hitchcock, E.R, 1990, The selective viability of human foetal brain cells, Brain Res., 520, 277–283.Google Scholar
  20. 20.
    Dunn, E.H., 1917, Primary and secondary findings in a series of attempts to transplant cerebral cortex in albino rat, J. Comp. Neurol., 271, 565–582.Google Scholar
  21. 21.
    Dunnett, S., Björklund, A., and Stenevi, U., 1983, Transplant-induced recovery from brain lesions. A review of the nigro-striatal model, in Neural Tissue Transplantation Research, R.B. Wallace, and G.D. Das, eds., pp. 191–216, Springer-Verlag, New York.Google Scholar
  22. 22.
    Fine, A, Hunt, S.P., Oertal, W.H., Nomoto, M., Chong, P.N., Bond, A. Waters, E., Temlett, J.A., Annett, L., Dunnett, S.R., Jenner, P., and Marsden, E.D., 1987, Transplantation of embryonic marmoset dopaminergic neurons to the corpus striatum of marmosets rendered Parkinsonian by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Prog. in Brain Res., 78, 479–489, Elsevier, Amsterdam.Google Scholar
  23. 23.
    Foetuses and Foetal Material, March 1988, Hansard, p. 243.Google Scholar
  24. 24.
    Freed, E.R, Breeze, R.E., Rosenberg, N.L., Barrett, I.N., and Rottenberg, D.A, 1989, Therapeutic effects of human foetal dopamine cells transplanted in a patient with Parkinson’s Disease, in Neural transplantation: from molecular bases to clinical application, Restorative NeuroL and Neurosci. Suppl., p. 231.Google Scholar
  25. 25.
    Freed, W.J., Morihisa, J.M. Spoor, E., Hoffer, B.J. Olson, L., Seiger, A., and Wyatt, R.J., 1981, Transplanted adrenal chromaffin cells in rat brain reduces lesion induced rotational behaviour, Nature, 292, 351–352.Google Scholar
  26. 26.
    Henderson, R.T.H., Clough, C.G., Hughes, R.C., Hitchcock, E.R., and Kenny, R.G., 1991, Implantation of human foetal ventral mesencephalon to the right caudate nucleus in advanced Parkinson’s Disease, Arch. Neurol., 48, 822–827.Google Scholar
  27. 27.
    Hitchcock, E.R, 1989, Recent experiences with dopamine transplantation for Parkinson’s Disease, in Proceedings of Society of British Neurological Surgeons, Oxford, J. Neurosurg. Psychiat., 52, 141.Google Scholar
  28. 28.
    Hitchcock, E.R., Kenny B.G., Clough E.G., Hughes, R.E., Henderson, R.T.H., and Detta, A., 1990, Stereotactic implantation of foetal mesencephalon (STIM): the UK. experience, Prog. in Brain Res., 82, 723–728, Elsevier, Amsterdam.Google Scholar
  29. 29.
    Isacson, O., Dunnett, S.R., and Björklund, A., 1986, Graft-induced behavioural recovery in an animal model of Huntington’s Disease, Proc. Nat. Acad. Sci., U.S.A, 83, 27–32.Google Scholar
  30. 30.
    Jiang, N., Jiang, E., Tang, Z., Zhung, F., and Jiang Li, S.D., 1987, Human foetal brain transplant trials in the treatment of Parkinsonism, Acta Academial Medicinae Shanghai, 14, No. 1.Google Scholar
  31. 31.
    Justice, A., Deckel, W., and Robinson, R.G., 1986, Foetal neocortical tissue survives transplantation into an ischaemic cortical site, Neurosci. Abs., 12, 1471.Google Scholar
  32. 32.
    Lampson, L.A., 1987, Molecular bases of the immune response to neural antigens, Trends in NeuroSci., 10, 211–216.Google Scholar
  33. 33.
    Le Gros Clarke, W.E., 1940, Neuronal differentiation in implanted foetal cortical tissue, Journal of NeuroL Psychiat., 3, 262–272.Google Scholar
  34. 34.
    Levivier, M., Sladek, Jr., J.R., Collier, T., Hagenmeyer-Houser, S.H., and Gash, D.M., 1989, The protective effect of various striatal implants on intrastriatal quinolinic application, Restorative Neurol. Neurosci., Suppl. 1.Google Scholar
  35. 35.
    Lindvall, O., Rehncrona, S., Brundin, P., Gustavi, B., Astedt, B. Widner, H., Lindholm, T., Björklund, A., Leenders, K, Rothwell, J.E., Frackowiak, R, Marsden, E.D., Johnels, B., Steg, G., Freedman, R., Hoffer, B.J., Seiger, A, Bygdeman, M., Stromberg, I., and Olson, L., 1989, Human foetal dopamine neurones grafted into the striatum in two patients with severe Parkinson’s Disease, Arch. Neurol., 46, 615–631.Google Scholar
  36. 36.
    Lindvall, O., Rehncrona, S., Gustavi, B., Brundin, P., Astedt, B., Widner, H., Linkholm, T., Björklund, A., Leenders, K.L., Rothwell, J.E., Frackowiak, R., Marsden, C.D., Johnels, B., Steg, G., Freedman, R., Hoffer, B.J., Seiger, A., Stromberg, I., Bygdeman, M., and Olson, L., 1988, Foetal dopamine-rich mesencephalic grafts in Parkinson’s Disease, Lancet, 1, 1483–1483.Google Scholar
  37. 37.
    Lund, R.D.Z., and Hauschka, S.D., 1976, Transplanted neural tissue develops connections with host rat brain, Science, 193, 582–584.Google Scholar
  38. 38.
    Madrazo, I., Drucker-Colin, R., Diaz, V., Martinez-Mata, J., Torres, E., and Becurri, J.J., 1987, Open microsurgical autograft of adrenal medulla to the right caudate nucleus in two patients with intractable Parkinson’s Disease, New Eng. J Med., 316, 831–834.Google Scholar
  39. 39.
    Madrazo, I., Leon, V., Torres, E., Aguilera, M.J.E., Valera, G., Alvarez, F., Fraga, A., Colin-Drucker., R, Ostrosky, F., Skurorich, M., and Franco, R. 1988, Transplantation of foetal substantia nigra and adrenal medulla to the caudate nucleus in two patients with Parkinson’s Disease, New Eng. J Med., 318, 51.Google Scholar
  40. 40.
    Medawer, P.B., 1948, Immunity to homologous grafted skin: III The fate of skin homografts transplanted to the brain to subcutaneous tissue, and to the anterior chamber of the eye, Brit. J Exp. Path., 29, 58–59.Google Scholar
  41. 41.
    Molina, H., 1989, Neurotransplantation in Parkinson’s Disease: The Cuban Experience, in Neuro transplantation: from molecular bases to clinical application, Restor. Neurol. and NeuroSci., Suppl. 1, 230.Google Scholar
  42. 42.
    Mundrick, L.A, Leung, P.P.H., Baimbrldge, K.G., and Miller, J.J., 1988, Neuronal transplants used in the repair of acute ischaemic injury in the central nervous system, Prog. in Brain Res., 78, 87–95, Elsevier, Amsterdam.Google Scholar
  43. 43.
    Parkinson’s Disease Society Newsletter, 1988,Issue No. 65.Google Scholar
  44. 44.
    Penn, R.D., Goetz, C.G. Tanner, E.M. Klawans, H.L., Shannon, K.M., Comella, C.L., and Witt, T.R., 1988, The adrenal medullary transplant operation for Parkinson’s Disease: clinical observations if five patients, Neurosurg., 22, 999–1004.Google Scholar
  45. 45.
    Perlow, M.J., Freed, W.J., Hoffer, B.J., Seiger, A., Olson, L., and Wyatt, RJ., 1979, Brain grafts reduce motor abnormalities produced by destruction of nigro-striatal dopamine systems, Science, 204, 643–646.Google Scholar
  46. 46.
    Pycock, C.J., 1980, Turning behaviour in animals, Neuroscience, 5, 461–514.Google Scholar
  47. 47.
    Report of Board of Social Responsibility, 1990, Human Transplants, Church of Scotland and Social Work.Google Scholar
  48. 48.
    Review of the guidance on the research use of foetuses and foetal material, 1989, Report of the Polkinghome Commission, HMSO CM, 762.Google Scholar
  49. 49.
    Sladek, J.R., Collier, J.J., Haber, S.N., Roth, R.H., and Redmond, E., 1986, Survival and growth of foetal catecholamines neurones transplanted into primate brain, Brain Res. Bull., 17, 809–818.Google Scholar
  50. 50.
    Sladek, J.R., and Gash, D.M., 1988, Nerve cell-grafting in Parkinson’s Disease, J. of Neurosurg., 68, 337–351.Google Scholar
  51. 51.
    Sladek, J.R, Redmond, D.E., Collier, T.J., Haaber, S.N., Elsworth, J.D., Deutsche, A.Y., and Roth, R.H., 1987, Transplantation of foetal dopamine neurons in primate brain reserves MPTP-induced Parkinsonism, Prog. in Brain Res., 71, 309–323, Elsevier, Amsterdam.Google Scholar
  52. 52.
    Sladek, J.R., and Shoulson, I., 1988, Neural transplantation: a call for patience rather than patients, Science, 240, 1386–1388.Google Scholar
  53. 53.
    Sotelo, C., and Alvarado-Mallart, R.M., 1988, Integration of grafted Purkinje cell into the host cerebellar circuitry in Purkinje cell degeneration mutant mouse. Prog. in Brain Res., 78, 141–154, Elsevier, Amsterdam.Google Scholar
  54. 54.
    Sotelo, S., and Alvarado-Mallart, R.M., 1987, Cerebellar transplantation in adult mice with here do-degenerative ataxia. Incell and tissue transplantation into the adult brain, eds., E.C. Azmita, and A. Björklund, Annals. N. Y. Acad. of Sci., 495, 242–167.Google Scholar
  55. 55.
    Statement of the Administrative Council of the World, 1989, Federation of Neurosurgical Societies.Google Scholar
  56. 56.
    Stromberg, I., Almquist, P., Bygdeman, M., Finger, T.E., Gerhardt, G., Granholme, A-Ch., Mahalik, T.J., Seiger, A., Hoffer, B., and Olson, L., 1988, Intracerebral zenografts of human mesencephalic tissue into athymic rats: immunocytochemical and in vivo electrochemical studies, Proc. Nat. Acad. Sci., USA, 85, 8331–8334.Google Scholar
  57. 57.
    Stromberg, I., Bygdeman, M., Goldstein, M., Seiger, A, and Olson, L., 1986, Human substantia nigra grafted to the dopamine denervated striatum of immunosuppressed rats: evidence for functional reinnervation, Neurosci. Letters, 71, 271–276.Google Scholar
  58. 58.
    The use of foetuses and foetal material for research, 1972, The Peel Report, HMSO.Google Scholar
  59. 59.
    Thompson, W.G., 1890, Successful brain grafting, New York Med. J., 51, 701–702.Google Scholar
  60. 60.
    Webster, D.D., 1968, Critical analysis of the disability in Parkinson’s Disease, Mod. Treat., 5, 257–282.Google Scholar
  61. 61.
    Weiss, R., 1988, Forbidding fruits of foetal cell research, Science News, 134, 289–304.Google Scholar
  62. 62.
    Woodruff, M.F.A, Hitchcock, E.R., and Whitehead, V.L., 1977, Effect of C parvum and active specific immunotherapy on intracerebral transplantation of a murine fibrosarcoma, Br. J. Cancer, 35, 687–692.Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Edward Hitchcock
    • 1
  1. 1.Department of NeurosurgeryUniversity of Birmingham MCNNSmethwick West MidlandsEngland

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