AIDS-Antiviral Natural Products Research at The U.S. National Cancer Institute

  • Kirk R. Gustafson
  • John H. CardellinaII
  • Kirk P. Manfredi
  • John A. Beutler
  • James B. McMahon
  • Michael R. Boyd

Abstract

The Laboratory of Drug Discovery Research and Development (LDDRD) is a new intramural NCI laboratory within the Division of Cancer Treatment’s Developmental Therapeutics Program. The primary research focus in LDDRD includes the development and refinement of the NCI anti-HIV and antitumor screening models, the bioassay-guided isolation of new active compounds and the detailed biological and pharmacological characterization of new leads. The NCI is currently testing crude extracts and pure compounds in an in vitro primary antiviral screen which detects the inhibition of HIV-induced cell killing. Extracts are additionally assayed in a disease-oriented, human 60 cell line in vitro antitumor screen representing 7 major categories of human cancer. Selected natural products extracts and pure compounds which demonstrate activity in these primary in vitro screens are subjected to further preclinical investigation within LDDRD. The goal of these efforts is to expeditiously identify and perform preclinical development studies of promising new clinical candidates.

Keywords

Flavonoid Alkaloid Glycoside Naphthalene Bark 

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Kirk R. Gustafson
    • 1
  • John H. CardellinaII
    • 1
  • Kirk P. Manfredi
    • 1
  • John A. Beutler
    • 1
  • James B. McMahon
    • 1
  • Michael R. Boyd
    • 1
  1. 1.Developmental Therapeutics ProgramLaboratory of Drug Discovery Research and DevelopmentFrederick

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