Proposal for Patient Selection Criteria and Follow-Up for BNCT in Patients with Supratentorial Malignant Gliomas

  • Heinz Fankhauser
  • Giuseppe Stragliotto


Treatment beam and irradiation room of the High Flux reactor in Petten are close to completion and pre-clinical dog irradiation studies were started in summer 1991. It is therefore timely to draft the preliminary protocol which will be applied to the initial patient study using borocaptate sodium (BSH) and epithermal neutrons for the treatment of malignant gliomas. At this stage emphasis is put on inclusion criteria, follow-up, and data collection, rather than on details of BNCT itself. The latter are to be finalized once the results of the irradiation at the treatment position of normal dogs with and without intravenously administered BSH are available.


Malignant Glioma Total Resection Partial Resection Boron Neutron Capture Therapy Stereotactic Biopsy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Jeffries, B.F.; Kishore, P.R.S.; Singh, K.S.; Ghatak, N.R.; Krempa, J. Contrast enhancement in the postoperative brain. Radiology 139, 409–413 (1981).PubMedGoogle Scholar
  2. 2.
    Ammirati, M.; Galicich, J.H.; Arbit, E.; Liao, Y. Reoperation in the treatment of recurrent intracranial malignant gliomas. Neurosurgery 21, 607–614 (1987).PubMedCrossRefGoogle Scholar
  3. 3.
    Harsh, G.R.; Levin, V.A.; Gutin, P.H.; Seager, M.; Silver, P.; Wilson, C.B. Reoperation for recurrent glioblastoma and anaplastic astrocytoma. Neurosurgery 21, 615–621 (1987).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Heinz Fankhauser
    • 1
  • Giuseppe Stragliotto
    • 1
  1. 1.Department of Neurosurgery CHUVLausanneSwitzerland

Personalised recommendations