RBE in Normal Tissue Studies

  • Reinhard A. Gahbauer
  • Ralph G. Fairchild
  • Joseph H. Goodman
  • Thomas E. Blue


Single dose RBEs for the radiations encountered in BNCT have been determined1 and can provide useful guidance for the tolerance to be expected. The difficulty of microdosimetric determination of dose2, the rapidly varying mix of constituent high and low LET radiations with depth, the possible synergistic interaction between high and low LET radiations3, and the strong dependence of biological efficacy on the distribution of boron within the cell are all factors limiting the usefulness of RBEs. Large animal studies arenecessary to determine late effect tolerance. To design, interpret, compare, and apply these studies to clinical use, it has been proposed to divide factors influencing “RBE” into two groups4; 1) estimated tolerance dose (ETD), which can be inferred from other experience reasonably well; and 2) compound factor (CF), which is much more variable as a function of microdosimetry and boron compound.


Fast Neutron Boron Concentration Boron Neutron Capture Therapy Relative Biological Effectiveness Boron Compound 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Reinhard A. Gahbauer
    • 1
  • Ralph G. Fairchild
    • 2
  • Joseph H. Goodman
    • 3
  • Thomas E. Blue
    • 4
  1. 1.Division of Radiation OncologyThe Ohio State UniversityColumbusUSA
  2. 2.Medical Department Brookhaven National Laboratory UptonUSA
  3. 3.Division of NeurosurgeryThe Ohio State UniversityColumbusUSA
  4. 4.Division of Nuclear EngineeringThe Ohio State UniversityColumbusUSA

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