Changes in Tissue Histology Associated with Adaptation and Acclimation to Hypoxia

  • Ian S. Longmuir
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 316)


The terms adaptation and hypoxia are both widely used but not always with quite the same meanings. Now that it is possible to measure the partial pressure of oxygen in every part of the mammalian organism with a fair degree of accuracy and a high degree of spatial resolution it seems appropriate to define hypoxia as a partial pressure of oxygen significantly lower than that normally found in that part of the organism. Thus an inspired Po2 of much less than 150 Torr and a Lubbers histogram of tissue oxygen tensions shifted to the left would both be defined as hypoxia.


Oxygen Consumption Liver Slice Tissue Oxygen Tension Mammalian Organism Reduce Oxygen Consumption 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Ian S. Longmuir
    • 1
  1. 1.Department of BiochemistryNorth Carolina State UniversityRaleighUSA

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