The Truncated TCA Cycle in HeLa Cell Mitochondria

  • Terrence J. Piva
  • Edward McEvoy-Bowe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 316)


A series of studies were carried out on HeLa cell mitochondria to determine (1) the likely pathways for carbon flux from glutamate, (2) the significance of malic enzyme activity, (3) the significance of pyruvate dehydrogenase activity, and finally (4) the significance of the truncated TCA cycle in HeLa cells (Coleman and Lavietes, 1981).


Malate Dehydrogenase Malic Enzyme Pyruvate Carboxylase Citrate Formation Major Amino Acid 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Terrence J. Piva
    • 1
  • Edward McEvoy-Bowe
    • 2
  1. 1.Department of BiochemistryUniversity of OxfordOxfordUK
  2. 2.Department of Chemistry & BiochemistryJames Cook University of North QueenslandTownsvilleAustralia

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