Cerebral Oxygenation State in Chemically-Induced Seizures in the Rat—Study by Near Infrared Spectrophotometry

  • Yoko Hoshi
  • Mamoru Tamura
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 316)


It is well known that cerebral blood flow (CBF) is markedly enhanced during seizure. However, whether the increase in blood flow results in the sufficient oxygen delivery to meet the increased demand is still controversial. The cerebral oxygen concentrations during seisure have been monitored by using oxygen electrode or spectrophotometry which measured the redox states of cytochrome oxidase(Cyt.ox.) or pyridine nucleotide in mitochondria. In previous paper, Hazeki and Tamura reported the quantitative analysis of hemoglobin(Hb) oxygenation state and the redox state of Cyt.ox. in the rat brain by using near infrared quadruple wavelength spectrophotometry(Hazeki et al. 1988). In this study, we will report the Hb oxygenation state and the redox state of Cyt.ox. in the rat brain during and after seizure.


Cerebral Blood Flow Redox State Cytochrome Oxidase Cerebral Blood Volume Oxygenation State 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Yoko Hoshi
    • 1
  • Mamoru Tamura
    • 1
  1. 1.Biophysics Division, Research Institute of Applied ElectricityHokkaido UniversitySapporoJapan

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