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Cerebral Oxygenation State in Chemically-Induced Seizures in the Rat—Study by Near Infrared Spectrophotometry

  • Yoko Hoshi
  • Mamoru Tamura
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 316)

Abstract

It is well known that cerebral blood flow (CBF) is markedly enhanced during seizure. However, whether the increase in blood flow results in the sufficient oxygen delivery to meet the increased demand is still controversial. The cerebral oxygen concentrations during seisure have been monitored by using oxygen electrode or spectrophotometry which measured the redox states of cytochrome oxidase(Cyt.ox.) or pyridine nucleotide in mitochondria. In previous paper, Hazeki and Tamura reported the quantitative analysis of hemoglobin(Hb) oxygenation state and the redox state of Cyt.ox. in the rat brain by using near infrared quadruple wavelength spectrophotometry(Hazeki et al. 1988). In this study, we will report the Hb oxygenation state and the redox state of Cyt.ox. in the rat brain during and after seizure.

Keywords

Cerebral Blood Flow Redox State Cytochrome Oxidase Cerebral Blood Volume Oxygenation State 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. B.Magnaes, B., and Nornes, H., 1974, “Circulatory and Respiratory Changes in spontaneous epileplic seizures in man.” Europ.Neurol. 12:104Google Scholar
  2. Dymond, A.M., and Crandall, P.H., “Oxygen availability and blood flow in the temporal lobes during spontaneous epileptic seizures in man.” Brain Research, 102:191Google Scholar
  3. F.G.Hempel, F.G., Kariman, K., and Saltzman, H.A., 1980 “Redox transitions in mitochondria of cat cortex with seizures and hemorragic hypotension.” Am.J.Physiol. 238:H249Google Scholar
  4. Hazeki, O., and Tamura, M., 1988, “Near infrared quadruple wavelength spectrophotometry of the rat head.” Adv.Exp.Med.Biol. 248:63Google Scholar
  5. Kreisman, N.R., J.C.Lamanna, J.C., Rosenthal, M., and Thomas, J., 1981, “Oxidative metablic responses with recurrent seizures in rat cerebral cortex: Role of systemic factors.” Brain Research, 218:175Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Yoko Hoshi
    • 1
  • Mamoru Tamura
    • 1
  1. 1.Biophysics Division, Research Institute of Applied ElectricityHokkaido UniversitySapporoJapan

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