Intravitreal and Intraretinal Oxygen Tension in the Rat Eye
The intravitreal and intraretinal oxygen distribution has been studied in several larger animals1,2,3 but never before in the rat. In fact the small vitreal volume (55µl)4 and large lens has previously dissuaded attempts at intraocular microelectrode work of any description. However, the advent of several rat models of retinal vascular disease has made this animal an attractive model in which to study retinal oxygenation, with a view to a better understanding of human diseases of a vascular nature. We therefore modified our techniques developed for larger animals to allow comparable measurements to be made in the rat. Vitreal oxygen tension distribution has been determined, with particular attention to the effects of retinal arteries and veins. The intraretinal oxygen tension profIle has also been categorised. The effects of hyperoxic ventilation were also investigated intravitreally and intraretinally. This control data will be vital to our future studies of the effects of vascular impairment in models of vascular disease.
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