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T Cell Adhesion Cascades: General Considerations and Illustration with CD31

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Mechanisms of Lymphocyte Activation and Immune Regulation IV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 323))

Abstract

Widespread appreciation of the importance of T cell adhesion has emerged only in the last 5-10 years. But now the topic is being widely discussed and many aspects carefully reviewed.1-8 This review briefly outlines one important emerging concept, namely that adhesion is not a simple unitary event but rather a co-ordinated sequence of events. This concept is emerging concurrently from studies in a variety of model systems.3,9-12 We illustrate how this concept has emerged from ours and others studies of T cells. Many aspects of T cell adhesion and biology are touched on which are beyond the scope of this brief presentation; the citations therefore emphasize reviews as a starting point for further reading.

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Authors and Affiliations

  1. Experimental Immunology Branch, National Cancer Institute National Institutes of Health, Bldg 10 Room 4B17, Bethesda, MD, 20892, USA

    Yoshiya Tanaka & Stephen Shaw

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  1. Yoshiya Tanaka
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  2. Stephen Shaw
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Editors and Affiliations

  1. University of California, Irvine, California, USA

    Sudhir Gupta

  2. National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

    Thomas A. Waldmann

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Tanaka, Y., Shaw, S. (1992). T Cell Adhesion Cascades: General Considerations and Illustration with CD31. In: Gupta, S., Waldmann, T.A. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation IV. Advances in Experimental Medicine and Biology, vol 323. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3396-2_20

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  • DOI: https://doi.org/10.1007/978-1-4615-3396-2_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6500-6

  • Online ISBN: 978-1-4615-3396-2

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