Abstract
It is now well accepted that T cell antigen receptor (TCR) engagement induces a cascade of protein phosphorylation with activation of both tyrosine and serine/threonine kinases. The most proximal events in this cascade appear to be the tyrosine phosphorylation of multiple intracellular proteins. This paper summarizes new data from our laboratory and places it in the context of observations made over the past several years. The initial problems that we and others have focused on are the identification and characterization of the kinases, phosphatases, and substrates that make up the elements of this pathway. With this information in hand, one can begin to understand the mechanism of signal transduction at a molecular level.
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Samelson, L.E., Egerton, M., Thomas, P.M., Wange, R.L. (1992). The T Cell Antigen Receptor Tyrosine Kinase Pathway. In: Gupta, S., Waldmann, T.A. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation IV. Advances in Experimental Medicine and Biology, vol 323. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3396-2_2
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DOI: https://doi.org/10.1007/978-1-4615-3396-2_2
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