B-Lymphocyte Lineage-Committed, IL-7 and Stroma Cell- Reactive Progenitors and Precursors, and Their Differentiation to B Cells

  • Fritz Melchers
  • Dirk Haasner
  • Martin Streb
  • Antonius Rolink
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 323)

Abstract

Long term lymphoid cell cultures from fetal liver and bone marrow1 have been used to study T- and B-lymphocyte development ‘in vitro’ and by repopulation experiments of suitable hosts ‘in vitro’2. Cell contacts between the progenitors of lymphocytes and stromal cells, as well as cytokines produced upon these contacts3 were found to be required for lymphopoiesis, specifically of the B-lymphocyte lineage4-6. Multiple contacts between stromal cells and progenitors have since been identified in this adhesion7-11. These early forms of progenitor and precursor cultures set the stage and raised the hope to dissect the hierarchy of hemopoietic-lymphopoietic differentiation to clone the differently committed cells, and to determine their capacity to proliferate and to differentiate.

Keywords

Migration Tyrosine Leukemia Integrin Myeloma 

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Fritz Melchers
    • 1
  • Dirk Haasner
    • 1
  • Martin Streb
    • 1
  • Antonius Rolink
    • 1
  1. 1.Basel Institute for ImmunologyBaselSwitzerland

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