Abstract
The T cell antigen receptor (TCR) is a multi-component cell surface complex composed of the products of at least six genes (1,2). Specific recognition of antigen/MHC is mediated by two chains of the TCR complex (generally ∝ and β) that are expressed as disulfide linked heterodimers and display a high degree of clonotypic diversity. Associated with this specialized heterodimer are the invariant dimers CD3 ε-δ and CD3 ε-γ and a disulfide-linked dimer formed by members of the ζ gene family (typically a ζ-ζ homodimer). The invariant chains of the TCR have been shown to be necessary for efficient assembly and transport of the receptor to the cell surface (3), and are also thought to be essential for signal transduction.
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© 1992 Springer Science+Business Media New York
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Engel, I., Letourneur, F., Houston, J.T.B., Ottenhoff, T.H.M., Klausner, R.D. (1992). T Cell Receptor Structure and Function: Analysis by Expression of Portions of Isolated Subunits. In: Gupta, S., Waldmann, T.A. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation IV. Advances in Experimental Medicine and Biology, vol 323. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3396-2_1
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DOI: https://doi.org/10.1007/978-1-4615-3396-2_1
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