Local Control of Murine Melanoma Xenografts in Nude Mice by Neutron Capture Therapy

  • B. J. Allen
  • S. Corderoy-Buck
  • D. E. Moore
  • Y. Mishima
  • M. Ichihashi

Abstract

In recent years considerable progress has been made in the development and implementation of neutron capture therapy (NCT) for the treatment of cancer. In particular, the boron analogue of the melanin precursor phenylalanine, ie DL-p-boronophenylalanine (BPA), has been used to demonstrate the regression and cure of Harding-Passey (HP) melanoma in syngeneic mice1. However, 18 to 25% cures were obtained for neutron irradiations without boron, suggesting that the neutron dose alone plays an important role. Neutron capture therapy of B-16 melanoma xenografts in nude mice2 showed substantial tumour regression over 35 days, but the survival rate of NCT treated mice after 7 weeks was only 40-60%.

Keywords

Graphite Boron Epoxy Glycol Bismuth 

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References

  1. 1.
    J.A. Coderre, J.A. Kalef-Ezra, R.J. Fairchild, P.L. Micca, L.E. Reinstein, J.D. Glass (1988). Boron neutron capture therapy of a murine melanoma, Cancer Res 48: 6313–6316PubMedGoogle Scholar
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    N. Tamaoki, M. Ueda, S. Tamauchi, K. Yamamoto, Y. Mishima (1989). Use of nude mice in experimental neutron capture therapy with 10B-BPA, Pigment Cell Res 2: 343–344.PubMedCrossRefGoogle Scholar
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    S.R. Tamat, D.E. Moore, B.J. Allen (1987). Determination of boron in biological tissues by inductively coupled plasma atomic emission spectrometry, Anal Chem 59: 1261–2164.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • B. J. Allen
    • 1
  • S. Corderoy-Buck
    • 1
  • D. E. Moore
    • 2
  • Y. Mishima
    • 3
  • M. Ichihashi
    • 3
  1. 1.Biomedicine and Health ProgramAustralian Nuclear Science and Technology Organisation PMB 1MenaiAustralia
  2. 2.Department of PharmacyUniversity of SydneyAustralia
  3. 3.Department of DermatologyUniversity of KobeKobeJapan

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