Ultrastructural Changes in Tumour Cells Following Boron Neutron Capture Therapy

  • D. H. Barkla
  • J. K. Brown
  • H. Meriaty
  • B. J. Allen

Abstract

In a previous study we reported on morphological changes in two human melanoma cell lines treated with 10B-phenylalanine(BPA) and Boron Neutron Capture Therapy(BNCT)1. The present study describes morphological changes in melanoma and glioma cell lines treated with boron-tetraphenyl porphyrin(BTPP) and BNCT. Porphyrin compounds are selectively taken up by tumour cells and have been used clinically in phototherapy treatment of cancer patients2. Boronated porphyrins show good potential as therapeutic agents in BNCT treatment of human cancer patients and the structure of these compounds is described in detail elsewhere in this monograph.

Keywords

Citrate Boron Rubber Penicillin Streptomycin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Barkla D.H., Allen B.J., Brown, J.K., Mountford, M., Mishima, Y. and Ichihashi, M. Morphological changes in human melanoma cells following irradiation with thermal neutrons. Pig. Cell Res. 2, 345–348, 1989.CrossRefGoogle Scholar
  2. 2.
    Morstyn G. and Kaye A.H. (Eds) Phototherapy of Cancer. Harwood Academic Press, Melbourne, 1990.Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • D. H. Barkla
    • 1
  • J. K. Brown
    • 2
  • H. Meriaty
    • 2
  • B. J. Allen
    • 2
  1. 1.Department of AnatomyMonash UniversityClayton VicAustralia
  2. 2.Australian Nuclear Science & Technology Organisation PMB 1MenaiAustralia

Personalised recommendations