Ultrastructural Changes in Tumour Cells Following Boron Neutron Capture Therapy
In a previous study we reported on morphological changes in two human melanoma cell lines treated with 10B-phenylalanine(BPA) and Boron Neutron Capture Therapy(BNCT)1. The present study describes morphological changes in melanoma and glioma cell lines treated with boron-tetraphenyl porphyrin(BTPP) and BNCT. Porphyrin compounds are selectively taken up by tumour cells and have been used clinically in phototherapy treatment of cancer patients2. Boronated porphyrins show good potential as therapeutic agents in BNCT treatment of human cancer patients and the structure of these compounds is described in detail elsewhere in this monograph.
KeywordsThermal Neutron Glioma Cell Line Boron Neutron Capture Therapy Human Melanoma Cell Line Cell Line U87MG
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- 2.Morstyn G. and Kaye A.H. (Eds) Phototherapy of Cancer. Harwood Academic Press, Melbourne, 1990.Google Scholar