Advertisement

Further in Vitro Radiobiological Analysis on 10B-BPA BNCT of Malignant Melanoma: Correlation of Determined 10B-Content and Cell Killing Effect

  • M. Ichihashi
  • M. Shiono
  • K. Yamamura
  • A. Komura
  • Y. Mishima
  • K. Yoshino
  • T. Kobayashi
  • K. Kanda
  • H. Fukuda
  • Y. Hori

Abstract

The successful application of boron neutron capture therapy (BNCT) for melanoma depends on the following points, (1) high accumulation of 10B in target melanoma cells (approcimately 20 ppm) and (2) high tumor/normal tissue10B ratio, theoretically greater than 5.

Keywords

Melanoma Cell Thermal Neutron Neutron Radiation Boron Neutron Capture Therapy Teflon Tube 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Mishima Y, Honda C, Ichihashi M, et al: Treatment of malignant manoma by single thermal neutron capture therapy with melanoma-seeking 10B- compound. Lancet 2:388, 1989.PubMedCrossRefGoogle Scholar
  2. 2.
    Hori Y, Nakamura K, Matsuoka M et al: Determination of 10B in biological samples by ICP-AES and IPC-MS. The 4th Japan-Australia International Workshop on Thermal Neutron Capture Therapy for Malignant Melanoma, Kobe, Feb. 13–17, 1989.Google Scholar
  3. 3.
    Ichihashi M, Sasase A,,iramoto T, et al: RBE of thermal neutron capture therapy using 10B1-paraboronophynelalanine for human and B-16 melanoma cells. Strahlen und Onkologie 165:198, 1989.Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • M. Ichihashi
    • 1
  • M. Shiono
    • 1
  • K. Yamamura
    • 1
  • A. Komura
    • 1
  • Y. Mishima
    • 1
  • K. Yoshino
    • 2
  • T. Kobayashi
    • 3
  • K. Kanda
    • 3
  • H. Fukuda
    • 4
  • Y. Hori
    • 5
  1. 1.Depts. Derm., Special Inst. Cancer Neutron Capture TherapyKobe Univ. Sch. Med.KobeJapan
  2. 2.Dept. Chem., Fac. Sci.Shinshu Univ.MatsumotoJapan
  3. 3.Kyoto Univ. Res Reactor Inst.OsakaJapan
  4. 4.Natl. Inst. Radiol. Sci.ChibaJapan
  5. 5.Shiseido Res. Cent.YokohamaJapan

Personalised recommendations