Determination of Boron Concentration in Tissues by Means of Alpha Autoradiography
The accurate measurement of total boron content in biological samples with a sensitivity in the ppm range is essential for evaluating the potential usefulness of various tumor localizing boron-containing compounds for Boron Neutron Capture Therapy (BNCT)1. A group of analytical procedures for boron quantitation are those involving nuclear methods. These include the detection of alpha particles resulting from the 10B(n,α,γ)7Li reaction by means of alpha track autoradiography2,3 and the measurement of gamma photons, by means of prompt gamma analysis4. The purpose of the present study was to develop alpha track autoradiography for microdistribution studies. It utilizes a solid state nuclear track detector (SSNTD), CR-39, which is composed of a polycarbonate resin, to record the charged products of the 10B(n, α)7Li reaction.
KeywordsBoron Concentration Boron Neutron Capture Therapy Track Density Solid State Nuclear Track Detector Common Coordinate System
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- 7.J.E. Woollard,T.E. Blue, J.F. Curran, M. C. Dobelbower, H. R. Busby: An Alpha Autoradiographic Technique for Spatial Quantification of Boron-10 Concentrations in Tissue, Nucl. Sci.and Eng.(in press).Google Scholar