Photodynamic Therapy of Brain Tumours
Cerebral tumours are responsible for approximately 2% of all cancer deaths and the high grade cerebral glioma is the most common cerebral tumour in adults. At the present time there is no satisfactory treatment for the malignant cerebral glioma. The best available treatment, using surgery, radiation therapy and systemic chemotherapy results in a median survival time of less than one year (Walker et al 1978; Walker et al 1980). In most cases surgery only provides a histological confirmation of the diagnosis and provides palliation of symptoms of raised intracranial pressure. Radiotherapy prolongs the median survival to 37 weeks and at present chemotherapy is of limited value when given by either conventional or the intracarotid route. Most treatment failures occur because of local recurrence of the tumour, indicating that a more aggressive local therapy to the tumour could be beneficial for the treatment of gliomas.
KeywordsPhotodynamic Therapy Malignant Brain Tumour Boron Neutron Capture Therapy Glioma Model Cerebral Tumour
Unable to display preview. Download preview PDF.
- Daniell M and Hill J. History of photodynamic therapy. Australian and New Zealand Journal of Surgery, 1990 (in press).Google Scholar
- Kaye AH and Hill J. Photoradiation therapy of brain tumours; Laboratory and clinical studies. In Phototherapy of Cancer. Editors, Morstyn G and Kaye AH. Harwood Academic Publishers, New York, 101–118, 1990.Google Scholar
- Raye AH, Morstyn G and Apuzzo MLJ. Photoradiation therapy and its potential in the management of neurological tumours. J. Neurosurg., 69: 114, 1988.Google Scholar
- Lipson RL, Baldes EJ and Olsen AM. Haematoporphyrin derivative: a new aid for endoscopic detection of malignant disease. J. Thoracic. Cardiovasc. Burg. 42: 623–629, 1961.Google Scholar
- McCullough GAJ, Forbes IJ, Lee See K, Cowled PA, Facka FJ and Ward AD. Phototherapy in malignant brain tumours. In: Doiron DR, Gomer CJ, Eds. Porphyrin localisation and treatment of tumours New York, NY: Alan Liss Inc., 709–717, 1984.Google Scholar
- Muller PJ and Wilson BC. Photodynamic therapy, cavitary photoillumination of malignant cerebral tumours using a laser couples inflatable balloon. Canc. J. Neurol. Sci. 12: 371–373, 1985.Google Scholar
- Perria C. Photodynamic therapy in human gliomas by haematoporphyrin and He-Ne laser. IRCS Med. Sci. (Cancer), 9: 57–58, 1981.Google Scholar