Neuronal Migration and Differentiation during Normal and Genetically Perturbed Development of the Hippocampal Formation

  • Richard S. Nowakowski
Part of the NATO ASI Series book series (NSSA, volume 217)


In order to understand the development of the various laminar organizational schemes which exist in the different parts of the adult CNS, it is necessary to understand three distinctly different cellular processes: cell proliferation, cell migration, and cell differentiation. Together these three steps can be considered to comprise “the life history” of a single neuron or glial cell; each cell must pass successively through all three of these steps in order to become a mature component of the CNS. Cell proliferation, cell migration, and cell differentiation occur simultaneously within every division and subdivision of the developing CNS, but for a single cell these steps represent a cascade of developmental events. Cells which pass through the cascade early can influence the fate of those cells which subsequently pass through the cascade. In other words, through intercellular interactions cells present in the same part of the nervous system, in the same or even in different states of maturation, can interact and affect each other’s fate. (For reviews see Nowakowski, 1987, 1991a).


Granule Cell Dentate Gyrus Pyramidal Cell Hippocampal Formation Mossy Fiber 
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© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Richard S. Nowakowski
    • 1
  1. 1.Department of Neuroscience and Cell BiologyUniversity of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical SchoolPiscatawayUSA

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