Structure and Classification of Retroviruses

  • John M. Coffin
Part of the The Viruses book series (VIRS)

Abstract

The retroviruses encompass a large family of infectious agents (Retroviridae) unified by a common virion structure and mode of replication. Retroviruses have been isolated from most vertebrate species in which they have been sought, and have been found to display a remarkable diversity in their association with the host. Table I gives a list of some of the more commonly encountered viruses. At the one end of the diversity, infections with some retroviruses can lead to uniformly fatal conditions, such as AIDS, a variety of malignancies, neurologic diseases, and other clinical conditions. At the other end, some retroviruses induce only a benign viremia with no outward adverse effects, and can even become established as DNA in the germ line and passed as “endogenous” viruses from generation to generation. Indeed, the line between endogenous viruses and the retrotransposable elements found in large numbers in the genome of all eukaryotes is very fine (Chapters 1 and 4). This chapter will be concerned with a discussion of general properties of the retroviruses, the structure of their virions, and their classification. Its scope will be limited to those elements which are demonstrably viruses.

Keywords

Lymphoma Leukemia Recombination Adenosine Sarcoma 

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© Springer Science+Business Media New York 1992

Authors and Affiliations

  • John M. Coffin
    • 1
  1. 1.Department of Molecular Biology and MicrobiologyTufts University School of MedicineBostonUSA

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