The Functional Role of T-Tubular Calcium Channels in Skeletal Muscle Contractions

  • George B. Frank
  • Murat Öz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)


Nearly 35 years ago, when I began my studies on the role of calcium ions in excitation-contraction (e-c) coupling in skeletal muscle there seemed to be excellent evidence supporting the concept that the e-c coupling process was identical during twitches and depolarization contractures (Frank, 1961). For this reason in my initial studies I used high K+-induced contractures in a Na+-free solution as a model for the events occurring during e-c coupling in both types of muscle activity (Frank, 1958, 1960).


Skeletal Muscle Sarcoplasmic Reticulum Skeletal Muscle Fiber Charge Movement Stimulus Train 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • George B. Frank
    • 1
  • Murat Öz
    • 1
  1. 1.Department of PharmacologyUniversity of AlbertaEdmontonCanada

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