Analysis of Factors Involved in the Tissue Selectivity of Calcium Antagonists
In functional studies, the term tissue selectivity is used for an agent showing varying degrees of potency among tissues with a preferential action in a given one. Such a selectivity is well known in the field of β-adrenoceptors, where β1 and β2 agonists and antagonists, differ by the ratio of activity at the level of a given tissue. Usually, this is related to their respective affinities for β1 and β2 adrenoceptors. Selectivity is not specificity which means that a given agent interacts with only one type of receptor. Such an interaction is largely documented in the field of histaminergic receptors where H1 antagonists do not interact with H2 receptors and vice versa. A question that has been raised several times (Godfraind et al., 1986), is the existence of a possible tissue selectivity of calcium antagonists. In other words, does any selectivity exist in the pharmacology of calcium channels ?
KeywordsCalcium Channel Calcium Antagonist Aortic Ring Calcium Entry Calcium Entry Blocker
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