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Correlation Between the Results of Functional and Receptor Binding Studies in Cardiac Muscle

  • E. Fejér
  • J. Szeredi
  • J. Gaál
  • P. Sz. Körmöczy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)

Abstract

Studies comparing the negative inotropic effect of calcium antagonists and “related” receptor-affinities showed inconsistent results. We tested the possible relationship between the potency in inhibiting CaCl2-induced positive inotropy and receptor affinity. Therefore, we determined the relative potency of Nifedipine, Verapamil, Fendiline, Bepridil and Diltiazem both in isolated rabbit papillary muscle against CaCl2-induced positive inotropy (pA2) and their relative affinity (-log KD) in receptor binding experiments in rat cardiac homogenates.

Keywords

Cardiac Muscle Relative Potency Negative Inotropic Effect Receptor Binding Affinity Receptor Binding Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • E. Fejér
    • 1
  • J. Szeredi
    • 1
  • J. Gaál
    • 1
  • P. Sz. Körmöczy
    • 1
  1. 1.CHINOIN Pharmaceutical & Chemical Works Co. Ltd.BudapestHungary

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