Modulation of L-Type Calcium Current in Mammalian Ventricular Myocytes by Photolysis of Caged Calcium

  • Susan E. Bates
  • Alison M. Gurney
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)


The caged calcium compound nitr-5 was used to investigate the effects of a rapid increase in intracellular calcium concentration on the L-type calcium current (ICa) of guinea pig ventricular cells. Short term inactivation and longer lasting potentiation were observed.


Ventricular MYOCYTES Intracellular Calcium Concentration Open Channel Block Single Time Constant Chelator BAPTA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Gurney AM, Charnet P, Pye JM and Nargeot J (1989) Augmentation of cardiac calcium current by flash photolysis of intracellular caged-Ca2+ molecules. Nature, 341:65–68PubMedCrossRefGoogle Scholar
  2. Harding SE, O’Gara P, Jones SM, Brown LA, Vescovo G and Poole-Wilson PA (1990) Species dependence of contraction velocity in single isolated cardiac myocytes. Cardioscience, 1:49–54PubMedGoogle Scholar
  3. Isenberg G and Klockner U (1882) Calcium tolerant ventricular myocytes prepared by preincubation in a “KB medium”. Pfluger Arch, 395:6–18CrossRefGoogle Scholar
  4. Kaplan JH and Ellis-Davies GCR (1988) Photolabile chelators for the rapid photorelease of divalent cations. Proc Natl Acad Sci USA, 85:6571–6575PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Susan E. Bates
    • 1
  • Alison M. Gurney
    • 1
  1. 1.Department of Pharmacology UMDSSt. Thomas’s HospitalLondonEngland

Personalised recommendations