Endothelium-Dependent and-Independent Relaxation of Aortas from Copper-Deficient Rats

  • Jack T. Saari
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)


Isolated aortas from copper-deficlent rats exhibited reduced ability to relax in response to acetylcholine, histamine and sodium nitroprusside, which suggests that release of endothelium-derived relaxing factor or its interaction with the contractile mechanism is impaired.


Sodium Nitroprusside Guanylate Cyclase Relaxation Response Toxic Trace Element Contractile Mechanism 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Jack T. Saari
    • 1
  1. 1.USDA, ARS, Human Nutrition Research Center Grand ForksUSA

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